9jq5

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Current revision (04:29, 14 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jq5 is ON HOLD until Paper Publication
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==Structure of human IVD in complex with FAD and isovaleryl-CoA==
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<StructureSection load='9jq5' size='340' side='right'caption='[[9jq5]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JQ5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IVC:ISOVALERYL-COENZYME+A'>IVC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jq5 OCA], [https://pdbe.org/9jq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jq5 RCSB], [https://www.ebi.ac.uk/pdbsum/9jq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jq5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IVD_HUMAN IVD_HUMAN] Defects in IVD are the cause of isovaleric acidemia (IVA) [MIM:[https://omim.org/entry/243500 243500]. IVA is characterized by retarded psychomotor development, a peculiar odor resembling sweaty feet, an aversion to dietary protein, and pernicious vomiting, leading to acidosis and coma. The acute neonatal form leads to massive metabolic acidosis from the first days of life and rapid death.<ref>PMID:2063866</ref> <ref>PMID:9665741</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IVD_HUMAN IVD_HUMAN]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bai F]]
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[[Category: Ju K]]
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[[Category: Luan X]]
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[[Category: Xu Y]]

Current revision

Structure of human IVD in complex with FAD and isovaleryl-CoA

PDB ID 9jq5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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