9dob
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Membrane-bound OlyA (E69A)/PlyB (Hinge-Lock) prepore focused refinement== | |
| - | + | <StructureSection load='9dob' size='340' side='right'caption='[[9dob]], [[Resolution|resolution]] 2.27Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dob]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pleurotus_ostreatus Pleurotus ostreatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DOB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.27Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A8R:(4S,7S)-4-hydroxy-7-[(1R,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphahexacos-17-en-1-aminium'>A1A8R</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dob OCA], [https://pdbe.org/9dob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dob RCSB], [https://www.ebi.ac.uk/pdbsum/9dob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dob ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OLYA6_PLEOS OLYA6_PLEOS] Has hemolytic activity against bovine erythrocytes at nanomolar concentrations in vitro. Promotes active pleurotolysin B (PlyB)-dependent permeabilization of membranes rich in cholesterol and sphingomyelin. May play an important role in the initial phase of fungal fruiting.<ref>PMID:12020804</ref> <ref>PMID:23806422</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pleurotus ostreatus]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Han Y]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Radhakrishnan A]] | ||
| + | [[Category: Smothers J]] | ||
Current revision
Membrane-bound OlyA (E69A)/PlyB (Hinge-Lock) prepore focused refinement
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