Insulin 3D Structures
From Proteopedia
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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* Insulin | * Insulin | ||
- | ** [[ | + | **[[1guj]], [[2c8q]], [[2c8r]], [[2lgb]], [[3i3z]], [[3i40]], [[3zi3]], [[4ak0]], [[5bts]], [[5en9]], [[6h3m]], [[6o17]], [[6s34]], [[7ac4]], [[7jp3]], [[7nhu]], [[7qgf]], [[7s4y]], [[7z5l]], [[7z5q]], [[8gsg]], [[8z4b]], [[9m50]], [[9m51]] - hIns A chain + B chain – human<br /> |
- | ** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction < | + | **[[6jr3]] - hIns A chain + B chain – Cryo EM<br /> |
- | ** [[ | + | **[[1g7a]], [[1g7b]], [[1mso]], [[1os3]], [[1os4]], [[1trz]], [[2qiu]], [[2vjz]], [[2vk0]], [[3e7y]], [[3e7z]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[5co2]], [[5co6]], [[5co9]], [[5ems]], [[5e7w]], [[6gv0]], [[6zi8]], [[8hgz]], [[9lvc]], [[9lvd]], [[9lve]], [[9m4x]], [[9m4y]], [[9m4z]] - hIns A chain + B chain + Zn<br /> |
- | ** [[ | + | **[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br /> |
- | ** [[ | + | **[[5t7r]], [[8rrp]] - hIns A chain (mutant) + B chain<br /> |
- | **[[ | + | **[[1b9e]], [[2ws4]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[7nhu]], [[8hsf]], [[8hsk]] - hIns A chain + B chain (mutant)<br /> |
- | ** | + | **[[1qj0]], [[3bxq]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn |
- | ** [[ | + | **[[2r34]], [[2r35]], [[2r36]], [[3exx]], [[3ilg]], [[3inc]], [[3ir0]], [[3tt8]], [[4fka]], [[4rxw]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br /> |
- | ** [[ | + | **[[1j73]], [[1jca]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br /> |
- | ** [[ | + | **[[5azz]], [[5mwq]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br /> |
- | ** [[ | + | **[[6p4z]] - hIns A chain + B chain + Co + Gd<br /> |
- | + | **[[2g4m]], [[3t2a]], [[4a7e]], [[5d52]], [[5d53]], [[5d54]], [[5d5e]], [[5fb6]], [[5lis]], [[9ins]] - pIns A chain + B chain – pig<br /> | |
- | **[[ | + | **[[1iza]] - pIns A chain + B chain (mutant)<br /> |
+ | **[[1zni]], [[3fhp]], [[3ins]], [[3rto]], [[4ins]] - pIns A chain + B chain + Zn<br /> | ||
+ | **[[1izb]] - pIns A chain + B chain (mutant) + Zn<br /> | ||
+ | **[[2efa]], [[2zpp]] - pIns A chain + B chain – Neutron<br /> | ||
+ | **[[1m5a]] - pIns A chain + B chain + Co<br /> | ||
+ | **[[6ins]] – pIns single chain<br /> | ||
+ | **[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[2bn1]], [[2bn3]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br /> | ||
+ | **[[2a3g]], [[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]] - bIns A chain + B chain + Zn <br /> | ||
+ | **[[6zhb]] - bIns A chain + B chain + Zn – electron diffraction<br /> | ||
+ | **[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br /> | ||
+ | **[[6q8q]] - bIns A chain + B chain + Ar <br /> | ||
- | * Insulin structures using NMR | + | *Insulin structures using NMR |
- | ** [[1sf1]], [[ | + | **[[1sf1]], [[1xgl]], [[2aiy]], [[2hiu]], [[2jv1]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2mvc]], [[3aiy]], [[4aiy]], [[5aiy]], [[6x4x]] - hIns A chain + B chain – NMR<br /> |
- | ** [[ | + | **[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br /> |
- | ** | + | **[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br /> |
- | ** [[ | + | **[[1a7f]], [[1jco]], [[1hiq]], [[1hit]], [[2h67]], [[2hho]], [[2jmn]], [[2kjj]], [[2k91]], [[2mvd]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<br /> |
- | ** [[ | + | **[[1hls]], [[1hui]], [[1k3m]], [[1lkq]], [[1mhi]], [[1mhj]], [[1vkt]], [[2jum]], [[2juv]], [[2m1d]] - hIns A chain (mutant) + B chain (mutant) – NMR<br /> |
- | ** [[ | + | **[[2kqq]], [[2l1y]] - hIns A chain (mutant) + B chain + Ala – NMR<br /> |
- | ** [[ | + | **[[2kjr]] - hIns A chain + B chain (mutant) + Ala – NMR<br /> |
- | ** [[ | + | **[[7elj]] - bIns A chain + B chain + tetrapeptide – NMR<br /> |
- | ** [[2lwz]], [[ | + | **[[2hh4]] - hIns A chain + B chain (mutant) + Ser – NMR<br /> |
- | **[[5miz]] - bIns A chain + B chain – NMR | + | **[[2kju]] - hIns A chain + B chain (mutant) + Glu – NMR<br /> |
+ | **[[2juu]] - hIns A chain (mutant) + B chain (mutant) + Thr – NMR<br /> | ||
+ | **[[1kmf]] - hIns A chain (mutant) + B chain (mutant) + Ile – NMR<br /> | ||
+ | **[[1bzv]] - hIns A chain (mutant) + B chain (mutant) + Ala – NMR<br /> | ||
+ | **[[2lwz]], [[5wbt]] – hIns single chain - NMR<br /> | ||
+ | **[[2jzq]] – hIns single chain (mutant) - NMR<br /> | ||
+ | **[[8rvt]] - hIns A chain 25-53 + hInsLis B chain 90-110 - NMR<br /> | ||
+ | **[[1ho0]] - bIns B chain (mutant) – NMR<br /> | ||
+ | **[[5miz]], [[6kh8]], [[6kh9]], [[6kha]] - bIns A chain + B chain – NMR<br /> | ||
- | * Insulin complexes | + | *Insulin complexes |
- | ** [[4xc4]] - hIns A chain + B chain + sulfatide< | + | **[[4xc4]] - hIns A chain + B chain + sulfatide + Zn<br /> |
- | ** [[1ben]] - hIns A chain + B chain + hydroxybenzamide< | + | **[[1ben]] - hIns A chain + B chain + hydroxybenzamide + Zn<br /> |
- | ** [[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide< | + | **[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide + Zn<br /> |
- | ** [[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol< | + | **[[8onp]], [[8onr]] - hIns A chain + B chain + hydroxyproline + Zn<br /> |
- | ** [[2omg]] - hIns A chain + B chain + urea + cresol<br /> | + | **[[5boq]] - hIns A chain + B chain + norleucine<br /> |
- | ** [[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate< | + | **[[5bpo]] - hIns A chain + B chain + norvaline<br /> |
- | ** [[ | + | **[[5bqq]] - hIns A chain + B chain + norvaline + Zn<br /> |
- | ** [[ | + | **[[2mli]] - hIns A chain + B chain + Phe derivative<br /> |
- | ** [[1qiy]] - hIns A chain + B chain (mutant) + phenol<br /> | + | **[[2ws1]] - hIns A chain + B chain + Tyr derivative<br /> |
- | ** [[ | + | **[[2wrw]], [[4cxl]], [[5hpr]], [[5hqi]] - hIns A chain + B chain (mutant) + Pro derivative<br /> |
- | ** [[ | + | **[[4nib]] - hIns A chain (mutant) + B chain + Ala <br /> |
- | ** [[ | + | **[[3fq9]] - hIns A chain (mutant) + B chain + Ala + Zn<br /> |
- | ** [[ | + | **[[2wru]], [[2wrx]], [[2ws0]], [[4cxn]], [[4cy7]] - hIns A chain + B chain (mutant) + Ala derivative<br /> |
- | ** [[ | + | **[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br /> |
- | ** [[ | + | **[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br /> |
- | ** [[ | + | **[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br /> |
- | **[[ | + | **[[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate + resorcinol + Zn<br /> |
- | **[[ | + | **[[1znj]], [[3v19]], [[4ajz]], [[4akj]] - hIns A chain + B chain + phenol + Zn<br /> |
- | **[[5mam]] - hIns A chain + B chain + serotonin <br /> | + | **[[1rwe]], [[1xw7]], [[3kq6]] - hIns A chain (mutant) + B chain + phenol + Zn<br /> |
- | **[[ | + | **[[1qiy]], [[1w8p]], [[2ws7]] - hIns A chain + B chain (mutant) + phenol + Zn<br /> |
- | ** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate< | + | **[[1lph]], [[1zeg]] - hIns A chain (mutant) + B chain (mutant) + phenol + Zn<br /> |
- | ** [[1mpj]] - pIns A chain + B chain + phenol<br /> | + | **[[3v1g]] - hIns A chain + B chain + phenol + Glu + Zn<br /> |
- | ** [[2tci]] - pIns A chain + B chain + thiocyanate< | + | **[[1q4v]] - hIns A chain + B chain + phenol + Ile + Zn<br /> |
- | ** [[3mth]] - pIns A chain + B chain + methylparaben< | + | **[[3p2x]], [[3rov]] - hIns A chain + B chain (mutant) + phenol + Ala + Zn<br /> |
- | ** [[ | + | **[[5hpu]], [[5uoz]], [[5uqa]], [[5urt]], [[5uru]], [[5usp]], [[5uss]], [[5usv]], [[5uu2]], [[5uu3]], [[5uu4]] - hIns A chain + B chain + phenol + Pro derivative + Zn<br /> |
- | ** [[7ins]] - pIns A chain + B chain + clupeine + | + | **[[5hrq]] - hIns A chain + B chain (mutant) + phenol + Pro derivative + Zn<br /> |
+ | **[[3zqr]], [[3zs2]] - hIns A chain + B chain + phenol + Phe derivative + Zn<br /> | ||
+ | **[[2ws6]] - hIns A chain + B chain + phenol + Tyr derivative + Zn<br /> | ||
+ | **[[1xda]] - hIns A chain + B chain + phenol + myristic acid + Zn<br /> | ||
+ | **[[6ck2]] - hIns A chain + B chain (mutant) + phenol + ornithine + Zn<br /> | ||
+ | **[[1qiz]] - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn<br /> | ||
+ | **[[1ev3]], [[1ev6]], [[1uz9]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[6gnq]] - hIns A chain + B chain + cresol + Zn<br /> | ||
+ | **[[1zeh]] - hIns A chain (mutant) + B chain (mutant) + cresol + Zn<br /> | ||
+ | **[[1evr]], [[3zu1]], [[4ajx]] - hIns A chain + B chain + resorcinol + Zn<br /> | ||
+ | **[[5mam]] - hIns A chain + B chain + serotonin + Zn<br /> | ||
+ | **[[5mt3]], [[5mt9]] - hIns A chain + B chain + serotonin + arginine + Zn<br /> | ||
+ | **[[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<br /> | ||
+ | **[[1mpj]], [[1wav]], [[3gky]] - pIns A chain + B chain + phenol + Zn<br /> | ||
+ | **[[2tci]] - pIns A chain + B chain + thiocyanate + Zn<br /> | ||
+ | **[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br /> | ||
+ | **[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br /> | ||
+ | **[[5jyq]] - CgIns A chain + B chain + Pro derivative – Conus geographus<br /> | ||
+ | |||
+ | *Insulin complexes with protein | ||
+ | |||
+ | **[[3q6e]] - hIns A chain + B chain + synthetic receptor<br /> | ||
+ | **[[7bw7]], [[7bw8]], [[7bwa]], [[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7qid]], [[7sth]], [[7sti]], [[7stj]], [[7stk]], [[8guy]] - hIns A chain + B chain + insulin receptor – Cryo EM<br /> | ||
+ | **[[7l7j]], [[7sl1]], [[7sl2]], [[7sl3]] - hIns A chain (mutant) + B chain + insulin receptor – Cryo EM<br /> | ||
+ | **[[7sl4]], [[7sl6]] - hIns A chain + B chain (mutant) + insulin receptor – Cryo EM<br /> | ||
+ | **[[7mqs]] - hIns A chain (mutant) + B chain (mutant) + insulin receptor – Cryo EM<br /> | ||
+ | **[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] - hIns A chain + B chain + insulin receptor + DNA – Cryo EM<br /> | ||
+ | **[[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme + Zn<br /> | ||
+ | **[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme <br /> | ||
+ | **[[6b3q]], [[6bfc]] - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM<br /> | ||
+ | **[[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn<br /> | ||
+ | **[[8oni]], [[8onk]] - hIns A chain + B chain enzyme + antibody<br /> | ||
+ | **[[3w11]], [[5kqv]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br /> | ||
+ | **[[6b70]] - hIns A chain + B chain + insulin-degrading enzyme + antibody – Cryo EM<br /> | ||
+ | **[[6jk8]], [[7v3p]] - hIns A chain + B chain + IGF-1R – Cryo EM<br /> | ||
+ | **[[8vjb]] - hIns A chain + B chain + IGF-2 – Cryo EM<br /> | ||
+ | **[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br /> | ||
+ | **[[4oga]], [[6vep]] - hIns A chain + B chain + insulin receptor + antibody<br /> | ||
+ | **[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]], [[6pxv]], [[6pxw]], [[6sof]] - hIns A chain + B chain + insulin receptor – Cryo EM<br /> | ||
+ | **[[6z7w]], [[6z7y]], [[6z7z]] - pIns A chain + B chain + antibody<br /> | ||
+ | **[[6z7z]] - pIns A chain + B chain + antibody<br /> | ||
+ | **[[7ins]] - pIns A chain + B chain + clupeine<br /> | ||
+ | **[[8ez0]] - mIns + insulin receptor – Cryo EM<br /> | ||
+ | **[[6veq]] - CgIns A chain + B chain + insulin receptor + antibody<br /> | ||
* Proinsulin | * Proinsulin | ||
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* Despeptide insulin | * Despeptide insulin | ||
- | ** [[2ceu]] – DPI – yeast<BR /> | ||
- | ** [[1sdb]] - pDPI A chain + B chain<BR /> | ||
- | ** [[1pid]] - bDPI A chain + B chain<BR /> | ||
** [[1his]] - hDPI A chain + B chain]] - NMR<BR /> | ** [[1his]] - hDPI A chain + B chain]] - NMR<BR /> | ||
** [[1htv]] – hDTRI A chain + B chain<BR /> | ** [[1htv]] – hDTRI A chain + B chain<BR /> | ||
+ | ** [[1sdb]] - pDPI A chain + B chain<BR /> | ||
** [[1dei]] – pDHPI A chain (mutant) + B chain (mutant) <BR /> | ** [[1dei]] – pDHPI A chain (mutant) + B chain (mutant) <BR /> | ||
- | ** [[2ins]] – bD-Phe Ins chain A + chain B | + | ** [[1pid]] - bDPI A chain + B chain<BR /> |
+ | ** [[2ins]] – bD-Phe Ins chain A + chain B<br /> | ||
+ | ** [[2ceu]] – DPI – yeast<BR /> | ||
* Leginsulin | * Leginsulin | ||
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*Insulin lispro | *Insulin lispro | ||
- | **[[5udp]] – | + | **[[5udp]] – LishIns – synthetic<br /> |
+ | **[[6nwv]] - hIns A chain + hInsLis B chain + cresol + Zn<br /> | ||
*Insulin glargine | *Insulin glargine | ||
**[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br /> | **[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br /> | ||
+ | **[[8wu0]] - hIns A chain + hInsLis B chain + Zn<br /> | ||
+ | |||
+ | *Insulin detemir | ||
+ | |||
+ | **[[8ipz]], [[9lvx]], [[9lvy]] - hIns A chain + hInsLis B chain + Zn<br /> | ||
+ | |||
+ | *Insulin desB30 precursor | ||
+ | **[[8pi4]], [[8pi5]], [[8pjc]], [[8pjh]] - hIns A chain 25-53 + hInsLis B chain 90-110 <br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] |
Current revision
(Updated on 24-September-2025)