Interferon regulatory factor

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Current revision (08:57, 28 September 2025) (edit) (undo)
 
Line 46: Line 46:
**[[2dll]] – hIRF IRF domain 8-115 - NMR<BR />
**[[2dll]] – hIRF IRF domain 8-115 - NMR<BR />
**[[6td4]] – hIRF DBD 20-139 (mutant)<br />
**[[6td4]] – hIRF DBD 20-139 (mutant)<br />
-
**[[7jm4]], [[7o56]], [[7ogs]], [[7oot]] – hIRF DBD + DNA<br />
+
**[[7jm4]], [[7o56]], [[7ogs]], [[7oot]], [[8jkl]] – hIRF DBD + DNA<br />
 +
**[[8jkn]], [[8jkq]], [[8jko]], [[8jks]] – hIRF DBD (mutant) + DNA<br />
**[[5bvi]] – mIRF IAD domain<br />
**[[5bvi]] – mIRF IAD domain<br />
Line 61: Line 62:
**[[5oem]] – mIRF IAD domain<br />
**[[5oem]] – mIRF IAD domain<br />
**[[5oen]] – mIRF IAD domain + STAT2<br />
**[[5oen]] – mIRF IAD domain + STAT2<br />
 +
 +
*Interferon regulatory factor 10
 +
 +
**[[8hcl]] – zIRF DBD + DNA - zebrafish<br />
 +
 +
*Interferon regulatory factor 11
 +
 +
**[[8hcs]] – zIRF DBD <br />
 +
**[[8hcm]] – zIRF DBD + DNA<br />
*Lytic viral interferon regulatory factor
*Lytic viral interferon regulatory factor

Current revision

Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry 1if1)

Drag the structure with the mouse to rotate

3D structures of interferon regulatory factor

Updated on 28-September-2025

References

  1. ↑ Paun A, Pitha PM. The IRF family, revisited. Biochimie. 2007 Jun-Jul;89(6-7):744-53. Epub 2007 Feb 20. PMID:17399883 doi:http://dx.doi.org/10.1016/j.biochi.2007.01.014
  2. ↑ Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 2004 Jul;24(14):6298-310. PMID:15226432 doi:http://dx.doi.org/10.1128/MCB.24.14.6298-6310.2004
  3. ↑ Weaver BK, Kumar KP, Reich NC. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol. 1998 Mar;18(3):1359-68. PMID:9488451
  4. ↑ Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Hocker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrucker HW, Huber M. The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi:, 10.1073/pnas.1309378110. Epub 2013 Aug 26. PMID:23980171 doi:http://dx.doi.org/10.1073/pnas.1309378110
  5. ↑ Suprunenko T, Hofer MJ. The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond. Cytokine Growth Factor Rev. 2016 Jun;29:35-43. doi:, 10.1016/j.cytogfr.2016.03.002. Epub 2016 Mar 4. PMID:26987614 doi:http://dx.doi.org/10.1016/j.cytogfr.2016.03.002
  6. ↑ Barnes B, Lubyova B, Pitha PM. On the role of IRF in host defense. J Interferon Cytokine Res. 2002 Jan;22(1):59-71. PMID:11846976 doi:http://dx.doi.org/10.1089/107999002753452665
  7. ↑ Chen HZ, Guo S, Li ZZ, Lu Y, Jiang DS, Zhang R, Lei H, Gao L, Zhang X, Zhang Y, Wang L, Zhu LH, Xiang M, Zhou Y, Wan Q, Dong H, Liu DP, Li H. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014 Sep 3;34(36):11897-912. doi: 10.1523/JNEUROSCI.1545-14.2014. PMID:25186738 doi:http://dx.doi.org/10.1523/JNEUROSCI.1545-14.2014
  8. ↑ Lohoff M, Duncan GS, Ferrick D, Mittrucker HW, Bischof S, Prechtl S, Rollinghoff M, Schmitt E, Pahl A, Mak TW. Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J Exp Med. 2000 Aug 7;192(3):325-36. PMID:10934221

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Michal Harel, Alexander Berchansky

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