7a5k

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Current revision (06:29, 1 October 2025) (edit) (undo)
 
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<StructureSection load='7a5k' size='340' side='right'caption='[[7a5k]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='7a5k' size='340' side='right'caption='[[7a5k]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a5k]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A5K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7a5k]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A5K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a5k OCA], [https://pdbe.org/7a5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a5k RCSB], [https://www.ebi.ac.uk/pdbsum/7a5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a5k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a5k OCA], [https://pdbe.org/7a5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a5k RCSB], [https://www.ebi.ac.uk/pdbsum/7a5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a5k ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/EFGM_HUMAN EFGM_HUMAN] Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1. The disease is caused by variants affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/EFGM_HUMAN EFGM_HUMAN] Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.[HAMAP-Rule:MF_03061]<ref>PMID:19716793</ref>
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[https://www.uniprot.org/uniprot/RM02_HUMAN RM02_HUMAN]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
== References ==

Current revision

Structure of the human mitoribosome in the post translocation state bound to mtEF-G1

PDB ID 7a5k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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