Lipase 3D Structures

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== 3D Structures of Lipase ==
== 3D Structures of Lipase ==
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*Eukaryote lipase:
*Eukaryote lipase:
-
**[[1hpl]] – hLip – horse <br />
 
**[[1hlg]] – hLip – human - gastric<br />
**[[1hlg]] – hLip – human - gastric<br />
**[[1jmy]] – hBSSL <br />
**[[1jmy]] – hBSSL <br />
-
**[[1akn]] – cBSSL – cattle <br />
+
**[[1hpl]] – hLip – horse <br />
-
**[[2bce]] - cBSSL (mutant) <br />
+
**[[9nrn]] – bLip – bovine - Cryo EM<br />
-
**[[1f6w]] - cBSSL – catalytic domain<br />
+
**[[2bce]] - bBSSL (mutant) <br />
 +
**[[1f6w]] - bBSSL – catalytic domain<br />
**[[3o0d]] – Lip – ''Yarrowia lipolytica''<br />
**[[3o0d]] – Lip – ''Yarrowia lipolytica''<br />
**[[4jei]] – YlLip (mutant)<br />
**[[4jei]] – YlLip (mutant)<br />
Line 19: Line 18:
**[[6a0w]] – Lip catalytic domain – bread mold<br />
**[[6a0w]] – Lip catalytic domain – bread mold<br />
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
 +
**[[1tic]], [[9jca]] – fLip – fungus<br />
 +
**[[9jc9]] – fLip (mutant) <br />
*Prokaryote lipase:
*Prokaryote lipase:
-
**[[1llf]] – Lip – ''Candida cylindracea''<br />
+
**[[1lpm]], [[1lps]] – CrLip closed state – ''Candida rugosa'' <br />
 +
**[[1crl]], [[1trh]] – CrLip open state<br />
 +
*[[1llf]] – Lip – ''Candida cylindracea''<br />
**[[3g7n]] – Lip - ''Penicillium expansum''<br />
**[[3g7n]] – Lip - ''Penicillium expansum''<br />
**[[1tia]] - Lip – ''Penicillium camemberti''<br />
**[[1tia]] - Lip – ''Penicillium camemberti''<br />
 +
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
 +
**[[6l7n]] – Lip – ''Penicillium roqueforti''<br />
**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
-
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]] - TlLip - ''Thermomyces lanuginose''<br />
+
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]], [[6xok]], [[6xrv]], [[6xs3]], [[7apn]], [[7app]] - TlLip - ''Thermomyces lanuginose''<br />
**[[5ap9]] – TlLip (mutant)<br />
**[[5ap9]] – TlLip (mutant)<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
-
**[[2lip]] – BcLip – open state<br />
+
**[[2lip]] – BcLip open state<br />
 +
**[[8xy5]] – Lip open state – ''Burkholderia stagnalis''<br />
**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
-
**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
 
-
**[[6qpr]] – RmLip (mutant)<br />
 
**[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state<br />
**[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state<br />
**[[2z8x]] - PsLip – extracellular<br />
**[[2z8x]] - PsLip – extracellular<br />
Line 51: Line 55:
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
-
**[[3umj]] – GzLip (mutant)<br />
+
**[[3umj]], [[7buk]] – GzLip (mutant)<br />
**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
**[[3ngm]] – Lip – ''Gibberella zeae''<br />
**[[3ngm]] – Lip – ''Gibberella zeae''<br />
**[[3auk]] - Lip – ''Geobacillus''<br />
**[[3auk]] - Lip – ''Geobacillus''<br />
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
-
**[[4hs9]] – Lip – ''Proteus mirabilis''<br />
+
**[[4hs9]] – PmLip – ''Proteus mirabilis''<br />
 +
**[[6jd9]] – PmLip (mutant) <br />
**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
-
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
+
**[[6khm]] – CuaLip open form – ''Cutibacterium acnes''<br />
 +
**[[6khk]], [[6khl]] – CuaLip closed form <br />
 +
**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
 +
**[[7q4h]] – TtLip – ''Thermoanaerobacter thermohydrosulfuricus''<br />
 +
**[[8yqj]], [[8yqp]] – Lip – ''Paracoccus kondratievae''<br />
 +
**[[8yzn]] – Lip – ''Pseudomonas lcaligenes''<br />
 +
**[[8oim]] – SpLip - ''Sphingomonas''<br />
 +
**[[9jcb]] – Lip – ''Kalmanozyma brasiliensis''<br />
 +
**[[8yzo]] – Lip – ''Aquipseudomonas alcaligenes''<br />
*Bacterial lipase A
*Bacterial lipase A
Line 71: Line 84:
**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
 +
**[[7r1k]], [[7r25]] – LipA – ''Bacillus pumilus''<br />
*Bacterial lipase B
*Bacterial lipase B
**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
-
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
+
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]], [[9evi]] – CaLipB (mutant) <br />
**[[5gv5]] - CaLipB + phosphonate<br />
**[[5gv5]] - CaLipB + phosphonate<br />
 +
**[[4k6h]] – CaLipB (mutant) <br />
**[[3icw]] – CaLipB (mutant) + phosphonate<br />
**[[3icw]] – CaLipB (mutant) + phosphonate<br />
**[[5x7k]] – SmLipB NBD <br />
**[[5x7k]] – SmLipB NBD <br />
-
**[[6isp]], [[6isq]], [[6isr]] – LipB (mutant) – ''Pseudozyma antarctica''<br />
+
**[[6isp]], [[6isq]], [[6isr]], [[6j1p]], [[6j1q]], [[6j1r]], [[6j1s]] – PaLipB (mutant) – ''Pseudozyma antarctica''<br />
 +
**[[6j1t]] – PaLipB (mutant) + product analog<br />
 +
**[[6tp8]] – PaLipB + substrate<br />
**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
 +
**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
 +
**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />
 +
**[[9fde]] - LipB + Lys – ''Moesziomyces antarcticus'' <br />
*Bacterial lipase C
*Bacterial lipase C
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*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate
*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate
 +
**[[8zvq]] – hHSL – Cryo EM<br />
**[[3k6k]] – EstE7(LIPE) – metagenome library<br />
**[[3k6k]] – EstE7(LIPE) – metagenome library<br />
**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
-
 
+
**[[6keu]], [[7ci0]], [[7cip]], [[7w8n]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
-
*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.
+
**[[6kf1]], [[6kf5]], [[6kf7]], [[7cih]] – ElEstE53(HSL) (mutant)<br />
-
 
+
-
**[[2rau]] - Lip – ''Sulfolobus solfataricus''<br />
+
-
**[[3bxp]], [[3d3n]] - Lip – ''Lactobacillus plantarum''<br />
+
-
**[[3e0x]] - Lip – ''Clostridium acetobutylicum''<br />
+
-
**[[1z8h]] – Lip – ''Nostoc sp.'' PCC 712<br />
+
-
**[[1vj3]] - Lip – ''Nostoc sp.'' <br />
+
-
**[[3bzw]] – Lip - ''Bacteroides thetaiotaomicron''<br />
+
-
**[[2pbl]] – Lip - ''Silicibacter''
+
*Lipase + inhibitors
*Lipase + inhibitors
Line 130: Line 143:
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4s0x]] – TlLip + lauric acid<br />
**[[4s0x]] – TlLip + lauric acid<br />
 +
**[[4gxn]] – PmLip + inhibitor<br />
 +
**[[8p7e]] – SpLip + inhibitor <br />
*Lipase conjugated with analogs to its reaction intermediates
*Lipase conjugated with analogs to its reaction intermediates
 +
**[[1lpn]] – CrLip+ dodecanesulfonate <br />
 +
**[[1lpo]], [[1lpp]] – CrLip+ hexadecanesulfonate<br />
 +
**[[3rar]] – CrLip + phosphonate derivative<br />
**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />
**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />
Line 139: Line 157:
**[[6h0t]] – hBAL (mutant) <br />
**[[6h0t]] – hBAL (mutant) <br />
**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
-
**[[1aql]] – bBAL+taurocholate - bovine<br />
+
**[[1akn]] – bBAL<br />
 +
**[[1f6w]] - bBAL catalytic domain
 +
**[[1aql]] – bBAL+taurocholate <br />
*Monoacylglycerol lipase
*Monoacylglycerol lipase
-
**[[3hju]], [[3jw8]] - hMAGL <BR />
+
**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
-
**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]] – hMAGL + inhibitor<br />
+
**[[3jwe]], [[3pe6]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]], [[8aqf]], [[8ptr]], [[8rvf]], [[9f8a]], [[9f8b]], [[9f8c]], [[9f8d]], [[9fy5]], [[9g4m]] – hMAGL + inhibitor<br />
 +
**[[8ptc]], [[8ptq]] – hMAGL (mutant) + inhibitor<br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
 +
**[[4zwn]] – yMAGL – yeast<br />
 +
**[[4zxf]] – yMAGLip + substrate analog<br />
 +
**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
 +
**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
 +
**[[9rhw]] – MtMAGL + inhibitor<br />
 +
**[[9rf2]], [[8rf5]] – MtMAGL (mutant) + inhibitor<br />
 +
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
 +
**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
**[[3rli]] – BaMAGL + PMSF<br />
**[[3rli]] – BaMAGL + PMSF<br />
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
-
**[[4zwn]] – yMAGL – yeast<br />
+
**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
-
**[[4zxf]] – yMAGLip + substrate analog<br />
+
**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />
-
**[[6eic]] – MAGLip – ''Mycobacterium tuberculosis''<br />
+
**[[8yye]] – Lip – ''Caldibacillus thermomylovorans''<br />
-
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
+
 
 +
*Triacylglycerol lipase
 +
 
 +
**[[6or3]] –TlTAGLip + palmitate<br />
 +
**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
 +
**[[6qpr]] – RmLip (mutant)<br />
 +
**[[8ze9]] – Lip (mutant) + phthalate – ''Sulfobacillus acidophilus''<br />
 +
**[[8spk]] – Lip1 – ''Moraxella'' <br />
*Lipase with substrate bound at active site
*Lipase with substrate bound at active site
Line 174: Line 210:
*Lipase 2 or esterase/lipase
*Lipase 2 or esterase/lipase
-
**[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]] - E/L - uncultured bacteria<br />
+
**[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]], [[6cl4]] - E/L - uncultured bacteria<br />
**[[3w9b]] - CaE/L <br />
**[[3w9b]] - CaE/L <br />
**[[4v2i]] - E/L - ''Thalassospira''<br />
**[[4v2i]] - E/L - ''Thalassospira''<br />
Line 182: Line 218:
**[[4bzz]], [[4bzw]] - LpE/L <br />
**[[4bzz]], [[4bzw]] - LpE/L <br />
**[[6gup]] - AfE/L <br />
**[[6gup]] - AfE/L <br />
 +
**[[6unv]] - E/L – ''Rasamsonia emersonii'' <br />
**[[1lgy]] – Lip2 – ''Rhizopus niveus''<br />
**[[1lgy]] – Lip2 – ''Rhizopus niveus''<br />
**[[1gz7]] - CrLip2 <br />
**[[1gz7]] - CrLip2 <br />
**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
-
}}
+
**[[6ksi]], [[8s9r]] – SaLip2 – Staphylococcus aureus<br />
 +
**[[6ksl]], [[8k7p]] – SaLip2 (mutant)<br />
 +
**[[6ksm]], [[9l3c]], [[9l3s]] – SaLip2 + drug<br />
 +
**[[8yib]] – SaLip2 + petroselinic acid<br />
 +
**[[8k7q]] – SaLip2 (mutant) + petroselinic acid<br /
 +
*Lipoprotein lipase
 +
 +
**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />
 +
**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Lipase

Updated on 27-October-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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