Lipase 3D Structures

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Current revision (09:13, 27 October 2025) (edit) (undo)
 
Line 9: Line 9:
**[[1jmy]] – hBSSL <br />
**[[1jmy]] – hBSSL <br />
**[[1hpl]] – hLip – horse <br />
**[[1hpl]] – hLip – horse <br />
-
**[[1akn]] – bBSSL – bovine <br />
+
**[[9nrn]] – bLip – bovine - Cryo EM<br />
**[[2bce]] - bBSSL (mutant) <br />
**[[2bce]] - bBSSL (mutant) <br />
**[[1f6w]] - bBSSL – catalytic domain<br />
**[[1f6w]] - bBSSL – catalytic domain<br />
Line 18: Line 18:
**[[6a0w]] – Lip catalytic domain – bread mold<br />
**[[6a0w]] – Lip catalytic domain – bread mold<br />
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
 +
**[[1tic]], [[9jca]] – fLip – fungus<br />
 +
**[[9jc9]] – fLip (mutant) <br />
*Prokaryote lipase:
*Prokaryote lipase:
Line 35: Line 37:
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
-
**[[2lip]] – BcLip – open state<br />
+
**[[2lip]] – BcLip open state<br />
 +
**[[8xy5]] – Lip open state – ''Burkholderia stagnalis''<br />
**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
**[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
**[[1tic]] - Lip – ''Rhizopus oryzae''<br />
Line 65: Line 68:
**[[6khk]], [[6khl]] – CuaLip closed form <br />
**[[6khk]], [[6khl]] – CuaLip closed form <br />
**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
-
**[[7q4h]] – TtLip – Thermoanaerobacter thermohydrosulfuricus<br />
+
**[[7q4h]] – TtLip – ''Thermoanaerobacter thermohydrosulfuricus''<br />
-
 
+
**[[8yqj]], [[8yqp]] – Lip – ''Paracoccus kondratievae''<br />
 +
**[[8yzn]] – Lip – ''Pseudomonas lcaligenes''<br />
 +
**[[8oim]] – SpLip - ''Sphingomonas''<br />
 +
**[[9jcb]] – Lip – ''Kalmanozyma brasiliensis''<br />
 +
**[[8yzo]] – Lip – ''Aquipseudomonas alcaligenes''<br />
*Bacterial lipase A
*Bacterial lipase A
Line 82: Line 89:
**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
**[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
-
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
+
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]], [[9evi]] – CaLipB (mutant) <br />
**[[5gv5]] - CaLipB + phosphonate<br />
**[[5gv5]] - CaLipB + phosphonate<br />
**[[4k6h]] – CaLipB (mutant) <br />
**[[4k6h]] – CaLipB (mutant) <br />
Line 93: Line 100:
**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />
**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />
 +
**[[9fde]] - LipB + Lys – ''Moesziomyces antarcticus'' <br />
*Bacterial lipase C
*Bacterial lipase C
Line 105: Line 113:
*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate
*Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate
 +
**[[8zvq]] – hHSL – Cryo EM<br />
**[[3k6k]] – EstE7(LIPE) – metagenome library<br />
**[[3k6k]] – EstE7(LIPE) – metagenome library<br />
**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
**[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
Line 135: Line 144:
**[[4s0x]] – TlLip + lauric acid<br />
**[[4s0x]] – TlLip + lauric acid<br />
**[[4gxn]] – PmLip + inhibitor<br />
**[[4gxn]] – PmLip + inhibitor<br />
 +
**[[8p7e]] – SpLip + inhibitor <br />
*Lipase conjugated with analogs to its reaction intermediates
*Lipase conjugated with analogs to its reaction intermediates
Line 147: Line 157:
**[[6h0t]] – hBAL (mutant) <br />
**[[6h0t]] – hBAL (mutant) <br />
**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
**[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
-
**[[1aql]] – bBAL+taurocholate - bovine<br />
+
**[[1akn]] – bBAL<br />
 +
**[[1f6w]] - bBAL catalytic domain
 +
**[[1aql]] – bBAL+taurocholate <br />
*Monoacylglycerol lipase
*Monoacylglycerol lipase
**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
-
**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]] – hMAGL + inhibitor<br />
+
**[[3jwe]], [[3pe6]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]], [[8aqf]], [[8ptr]], [[8rvf]], [[9f8a]], [[9f8b]], [[9f8c]], [[9f8d]], [[9fy5]], [[9g4m]] – hMAGL + inhibitor<br />
 +
**[[8ptc]], [[8ptq]] – hMAGL (mutant) + inhibitor<br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
Line 159: Line 172:
**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
 +
**[[9rhw]] – MtMAGL + inhibitor<br />
 +
**[[9rf2]], [[8rf5]] – MtMAGL (mutant) + inhibitor<br />
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
Line 167: Line 182:
**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />
**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />
 +
**[[8yye]] – Lip – ''Caldibacillus thermomylovorans''<br />
*Triacylglycerol lipase
*Triacylglycerol lipase
Line 173: Line 189:
**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
**[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
**[[6qpr]] – RmLip (mutant)<br />
**[[6qpr]] – RmLip (mutant)<br />
 +
**[[8ze9]] – Lip (mutant) + phthalate – ''Sulfobacillus acidophilus''<br />
 +
**[[8spk]] – Lip1 – ''Moraxella'' <br />
*Lipase with substrate bound at active site
*Lipase with substrate bound at active site
Line 205: Line 223:
**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
**[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
**[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
-
**[[6ksi]] – SaLip2 – ''Staphylococcus aureus''<br />
+
**[[6ksi]], [[8s9r]] – SaLip2 – Staphylococcus aureus<br />
-
**[[6ksl]] – SaLip2 (mutant)<br />
+
**[[6ksl]], [[8k7p]] – SaLip2 (mutant)<br />
-
**[[6ksm]] – SaLip2 + drug<br />
+
**[[6ksm]], [[9l3c]], [[9l3s]] – SaLip2 + drug<br />
 +
**[[8yib]] – SaLip2 + petroselinic acid<br />
 +
**[[8k7q]] – SaLip2 (mutant) + petroselinic acid<br /
*Lipoprotein lipase
*Lipoprotein lipase
Line 214: Line 234:
**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
}}
}}
- 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Lipase

Updated on 27-October-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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