Liver receptor homolog-1
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='5l11' size='400' side='right' caption='Human LRH-1 (deepskyblue) complex with TIF-2 peptide (green) and an agonist (PDB code [[5l11]])' scene='77/777031/Cv/1'> |
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== Function == | == Function == | ||
| - | '''Liver receptor homolog-1''' (LRH-1) is a nuclear receptor which has critical functions in embryonic development and adult homeoestasis. LRH-1 is a key modulator of female fertility. LRH-1 plays a predominant role in development, reverse cholesterol transport, bile-acid homeostasis and steroidogenesis<ref>PMID:15130581</ref>. | + | '''Liver receptor homolog-1''' (LRH-1) or '''nuclear receptor subfamily 5 group A member 2''' is a nuclear receptor which has critical functions in embryonic development and adult homeoestasis. LRH-1 is a key modulator of female fertility. LRH-1 plays a predominant role in development, reverse cholesterol transport, bile-acid homeostasis and steroidogenesis<ref>PMID:15130581</ref>. |
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| + | See also [[Intracellular receptors]] | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The ligand of LRH-1 binds deep in the binding pocket and is fully engulfed by it<ref>PMID:27694445</ref>. | + | The <scene name='77/777031/Cv/2'>ligand of LRH-1 binds deep in the binding pocket and is fully engulfed by it</scene><ref>PMID:27694445</ref>. <scene name='77/777031/Cv/4'>Agonist binding site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of liver receptor homolog-1 == | == 3D Structures of liver receptor homolog-1 == | ||
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[[4is8]] – hLRH1 LBD – human <br /> | [[4is8]] – hLRH1 LBD – human <br /> | ||
| - | [[1pk5]] – mLRH1 LBD – mouse <br /> | ||
| - | [[3f5c]] – mLRH1 LBD (mutant) + DAX-1 peptide <br /> | ||
[[3tx7]] – hLRH1 LBD + catenin + phospholipid <br /> | [[3tx7]] – hLRH1 LBD + catenin + phospholipid <br /> | ||
[[4pld]] – hLRH1 LBD + NCOA-2 peptide + phospholipid<br /> | [[4pld]] – hLRH1 LBD + NCOA-2 peptide + phospholipid<br /> | ||
| - | [[1yok]], [[ | + | [[1yok]], [[1zdu]], [[4dos]], [[4ple]] – hLRH1 LBD + NCOA-2 peptide + phospholipid <br /> |
| - | [[5l11]], [[5syz]] – hLRH1 LBD + NCOA-2 peptide + agonist <br /> | + | [[5l11]], [[5syz]], [[6oqx]], [[6oqy]], [[6or1]], [[6vc2]], [[6vif]], [[7jyd]], [[7jye]], [[7tt8]], [[9smq]] – hLRH1 LBD + NCOA-2 peptide + agonist <br /> |
| - | [[ | + | [[8f8m]] – hLRH1 LBD + NCOA-2 peptide + modulator<br /> |
| + | [[1yuc]], [[4oni]] – hLRH1 LBD + nuclear receptor 0B2 peptide + phospholipid <br /> | ||
[[1zh7]] – hLRH1 LBD + SHP peptide <br /> | [[1zh7]] – hLRH1 LBD + SHP peptide <br /> | ||
[[4dor]] – hLRH1 LBD + SHP peptide + phospholipid <br /> | [[4dor]] – hLRH1 LBD + SHP peptide + phospholipid <br /> | ||
[[4rwv]] – hLRH1 LBD + DAX-1 peptide + phospholipid <br /> | [[4rwv]] – hLRH1 LBD + DAX-1 peptide + phospholipid <br /> | ||
[[5unj]] – hLRH1 LBD + PGC1A peptide + phospholipid <br /> | [[5unj]] – hLRH1 LBD + PGC1A peptide + phospholipid <br /> | ||
| - | [[2a66]], [[5l0m]] – hLRH1 DBD + DNA <br /> | + | [[2a66]], [[5l0m]] – hLRH1 DBD 79-187 + DNA <br /> |
| + | [[8pki]] – hLRH1 39-132 + nucleosome – Cryo EM <br /> | ||
| + | [[1pk5]] – mLRH1 LBD – mouse <br /> | ||
| + | [[3f5c]] – mLRH1 LBD (mutant) + DAX-1 peptide <br /> | ||
== References == | == References == | ||
Current revision
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3D Structures of liver receptor homolog-1
Updated on 27-October-2025
4is8 – hLRH1 LBD – human
3tx7 – hLRH1 LBD + catenin + phospholipid
4pld – hLRH1 LBD + NCOA-2 peptide + phospholipid
1yok, 1zdu, 4dos, 4ple – hLRH1 LBD + NCOA-2 peptide + phospholipid
5l11, 5syz, 6oqx, 6oqy, 6or1, 6vc2, 6vif, 7jyd, 7jye, 7tt8, 9smq – hLRH1 LBD + NCOA-2 peptide + agonist
8f8m – hLRH1 LBD + NCOA-2 peptide + modulator
1yuc, 4oni – hLRH1 LBD + nuclear receptor 0B2 peptide + phospholipid
1zh7 – hLRH1 LBD + SHP peptide
4dor – hLRH1 LBD + SHP peptide + phospholipid
4rwv – hLRH1 LBD + DAX-1 peptide + phospholipid
5unj – hLRH1 LBD + PGC1A peptide + phospholipid
2a66, 5l0m – hLRH1 DBD 79-187 + DNA
8pki – hLRH1 39-132 + nucleosome – Cryo EM
1pk5 – mLRH1 LBD – mouse
3f5c – mLRH1 LBD (mutant) + DAX-1 peptide
References
- ↑ Fayard E, Auwerx J, Schoonjans K. LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol. 2004 May;14(5):250-60. doi: 10.1016/j.tcb.2004.03.008. PMID:15130581 doi:http://dx.doi.org/10.1016/j.tcb.2004.03.008
- ↑ Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, Auwerx J. Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep. 2002 Dec;3(12):1181-7. doi: 10.1093/embo-reports/kvf238. Epub 2002 Nov , 21. PMID:12446566 doi:http://dx.doi.org/10.1093/embo-reports/kvf238
- ↑ Duggavathi R, Volle DH, Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, Schoonjans K. Liver receptor homolog 1 is essential for ovulation. Genes Dev. 2008 Jul 15;22(14):1871-6. doi: 10.1101/gad.472008. PMID:18628394 doi:http://dx.doi.org/10.1101/gad.472008
- ↑ Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K, Sugimoto H. StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria. J Biol Chem. 2016 Nov 25;291(48):24880-24891. doi: 10.1074/jbc.M116.736793. Epub , 2016 Sep 30. PMID:27694445 doi:http://dx.doi.org/10.1074/jbc.M116.736793
