9s70

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'''Unreleased structure'''
 
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The entry 9s70 is ON HOLD
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==Crystal structure of RXR alpha LBD bound to a partial agonist 21 and a coactivator fragment SRC1==
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<StructureSection load='9s70' size='340' side='right'caption='[[9s70]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Morozov, V., Merk, D., Lewandowski, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9s70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S70 FirstGlance]. <br>
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Description: Crystal structure of RXR alpha LBD bound to a partial agonist MAD26 and a coactivator fragment SRC1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JL7:3-[[4-cyclobutyl-6-(3,4-dihydro-2~{H}-quinolin-1-yl)pyrimidin-2-yl]amino]propanoic+acid'>A1JL7</scene></td></tr>
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[[Category: Merk, D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s70 OCA], [https://pdbe.org/9s70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s70 RCSB], [https://www.ebi.ac.uk/pdbsum/9s70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s70 ProSAT]</span></td></tr>
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[[Category: Morozov, V]]
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</table>
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[[Category: Lewandowski, M]]
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== Function ==
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[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lewandowski M]]
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[[Category: Merk D]]
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[[Category: Morozov V]]

Current revision

Crystal structure of RXR alpha LBD bound to a partial agonist 21 and a coactivator fragment SRC1

PDB ID 9s70

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