9h77
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==MPP8 chromodomain in complex with nanobody 3A02== | |
| - | + | <StructureSection load='9h77' size='340' side='right'caption='[[9h77]], [[Resolution|resolution]] 2.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9h77]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H77 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h77 OCA], [https://pdbe.org/9h77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h77 RCSB], [https://www.ebi.ac.uk/pdbsum/9h77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h77 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Bayliss | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bayliss R]] | ||
| + | [[Category: Richards MW]] | ||
Current revision
MPP8 chromodomain in complex with nanobody 3A02
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