9hrp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of YIUA from Yersinia ruckeri with iron== | |
| + | <StructureSection load='9hrp' size='340' side='right'caption='[[9hrp]], [[Resolution|resolution]] 2.32Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9hrp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_ruckeri Yersinia ruckeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HRP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hrp OCA], [https://pdbe.org/9hrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hrp RCSB], [https://www.ebi.ac.uk/pdbsum/9hrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hrp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A085U4N5_YERRU A0A085U4N5_YERRU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The marine pathogen Yersinia ruckeri synthesizes the tri-catecholate siderophore ruckerbactin, Rb, (DHB-(L)Arg-(L)Ser)(3), to acquire iron during infection. Its biosynthetic gene cluster encodes a single periplasmic binding protein, RupB, which surprisingly does not bind Fe(III)-Rb nor the Fe(III) complexes of its hydrolysis products, the di- and mono-catecholate siderophores Rb(DC) and Rb(MC), with biologically relevant affinities. Instead, the periplasmic binding protein YiuA, encoded in a different region of the chromosome, binds the 1 : 2 Fe(III) complex of the mono-catecholate Rb(MC), Fe(III)-(Rb(MC))(2). YiuA is the first periplasmic binding protein (PBP) to selectively recognize a mono-catecholate siderophore, the structural basis of which was illuminated through X-ray crystallography of YiuA bound to Fe(III)-(Rb(MC))(2). | ||
| - | + | Yersinia ruckeri YRB periplasmic binding protein YiuA selectively recognizes a Fe(III)-mono-catecholate siderophore.,Thomsen E, Thompson S, Stow PR, Cukor M, Grogan G, Duhme-Klair AK, Butler A Chem Commun (Camb). 2025 Oct 16. doi: 10.1039/d5cc05103g. PMID:41098114<ref>PMID:41098114</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 9hrp" style="background-color:#fffaf0;"></div> |
| - | [[Category: Butler | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yersinia ruckeri]] | ||
| + | [[Category: Butler A]] | ||
| + | [[Category: Duhme-Klair A]] | ||
| + | [[Category: Grogan G]] | ||
| + | [[Category: Thompson S]] | ||
| + | [[Category: Thomsen E]] | ||
Current revision
Structure of YIUA from Yersinia ruckeri with iron
| |||||||||||
