9n88

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m (Protected "9n88" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9n88 is ON HOLD
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==PROTAC-induced IRE1 ternary complex==
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<StructureSection load='9n88' size='340' side='right'caption='[[9n88]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9n88]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N88 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWF:(2~{S},4~{R})-1-[(2~{S})-3,3-dimethyl-2-[5-[4-[4-[(7-oxidanylidene-8-propan-2-yl-pyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]piperazin-1-yl]pentanoylamino]butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide'>A1BWF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n88 OCA], [https://pdbe.org/9n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n88 RCSB], [https://www.ebi.ac.uk/pdbsum/9n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n88 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ashkenazi A]]
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[[Category: Azumaya C]]
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[[Category: Du J]]
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[[Category: Hsu PL]]
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[[Category: Johnson M]]
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[[Category: Rohou A]]

Current revision

PROTAC-induced IRE1 ternary complex

PDB ID 9n88

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OCA

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