Mouse Vdac1: BI3323-Aug2025
From Proteopedia
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==Your Heading Here (maybe something like 'Structure of mouse VDAC1 at 2.3 Å')== | ==Your Heading Here (maybe something like 'Structure of mouse VDAC1 at 2.3 Å')== | ||
| - | <StructureSection load=' | + | <StructureSection load='3EMN' size='340' side='right' caption='Caption for this structure' scene=''> |
== Introduction == | == Introduction == | ||
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mVDAC1 forms a 19 stranded β-barrel - the first high resolution eukaryotic β-barrel with an odd number of strands. Strands 1 an 19 are in a parallel orientation to close the barrel while the rest are antiparallel. The pore is wide, elliptical and hydrophilic consistent with the open state. A key finding is the well resolved N-terminal α-helix positioned against the barrel's interior wall, partially narrowing the pore and contributing positive charges that shape anion selectivity. The helix is tethered to the wall by multiple hydrogen bonds and connected through a conserved glycine-rich hinge that may enable gating through helix repositioning. | mVDAC1 forms a 19 stranded β-barrel - the first high resolution eukaryotic β-barrel with an odd number of strands. Strands 1 an 19 are in a parallel orientation to close the barrel while the rest are antiparallel. The pore is wide, elliptical and hydrophilic consistent with the open state. A key finding is the well resolved N-terminal α-helix positioned against the barrel's interior wall, partially narrowing the pore and contributing positive charges that shape anion selectivity. The helix is tethered to the wall by multiple hydrogen bonds and connected through a conserved glycine-rich hinge that may enable gating through helix repositioning. | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample | + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scen<Structure load='3EMN' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />es.==Your Heading Here (maybe something like 'Structure')== |
<StructureSection load='3emn' size='350' side='right' caption='Crystal structure of mouse VDAC1 (PDB entry [[3emn]])' scene=''> | <StructureSection load='3emn' size='350' side='right' caption='Crystal structure of mouse VDAC1 (PDB entry [[3emn]])' scene=''> | ||
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== References == | == References == | ||
R. Ujwal, D. Cascio, J. Colletier, S. Faham, J. Zhang, L. Toro, P. Ping, & J. Abramson, The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating, Proc. Natl. Acad. Sci. U.S.A. 105 (46) 17742-17747, https://doi.org/10.1073/pnas.0809634105 (2008). | R. Ujwal, D. Cascio, J. Colletier, S. Faham, J. Zhang, L. Toro, P. Ping, & J. Abramson, The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating, Proc. Natl. Acad. Sci. U.S.A. 105 (46) 17742-17747, https://doi.org/10.1073/pnas.0809634105 (2008). | ||
| - | <references/>[[Link title]] | + | <references/>[[Link title]] |
Revision as of 15:24, 29 November 2025
Your Heading Here (maybe something like 'Structure of mouse VDAC1 at 2.3 Å')
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</StructureSection>
References
R. Ujwal, D. Cascio, J. Colletier, S. Faham, J. Zhang, L. Toro, P. Ping, & J. Abramson, The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating, Proc. Natl. Acad. Sci. U.S.A. 105 (46) 17742-17747, https://doi.org/10.1073/pnas.0809634105 (2008). Link title
