MDM2 3D structures
From Proteopedia
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*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491 | *'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491 | ||
| - | **[[2ruh]] - hMDM2 p53-binding domain | + | **[[8bgu]] - hMDM2 + RNA - human<br /> |
| + | **[[2ruh]] - hMDM2 p53-binding domain <br /> | ||
**[[1z1m]] – hMDM2 p53-binding domain - NMR<br /> | **[[1z1m]] – hMDM2 p53-binding domain - NMR<br /> | ||
**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br /> | **[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br /> | ||
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**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br /> | **[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br /> | ||
| - | **[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]] - hMDM2 + inhibitor<br /> | + | **[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br /> |
**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br /> | **[[5z02]], [[5zxf]] - hMDM2 + nutlin<br /> | ||
| + | **[[8pwc]] - hMDM2 + brigimadlin<br /> | ||
**[[2lzg]] - hMDM2 + inhibitor – NMR<br /> | **[[2lzg]] - hMDM2 + inhibitor – NMR<br /> | ||
**[[3vbg]] - hMDM2 + indolyl hydantoin<br /> | **[[3vbg]] - hMDM2 + indolyl hydantoin<br /> | ||
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**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br /> | **[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br /> | ||
**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br /> | **[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br /> | ||
| - | **[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], ]] | + | **[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]], [[8gcg]], [[8j81]], [[9cdz]], [[9fql]] - hMDM2 p53-binding domain + peptide inhibitor<br /> |
| - | **[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br /> | + | **[[5vk0]], [[6kzu]], [[6aaw]], [[9gfc]], [[9gfk]] - hMDM2 p53-binding domain + stapled peptide<br /> |
**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br /> | **[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br /> | ||
| + | **[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br /> | ||
**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br /> | **[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br /> | ||
**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br /> | **[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br /> | ||
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**[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br /> | **[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br /> | ||
| - | **[[5wts]] - hMDM2 p53-binding domain + GFP-linked peptide<br /> | ||
**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br /> | **[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br /> | ||
**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br /> | **[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br /> | ||
**[[7aye]] - hMDM2 p53-binding domain + DsbD<br /> | **[[7aye]] - hMDM2 p53-binding domain + DsbD<br /> | ||
| + | **[[8ei9]], [[8eia]], [[8eib]], [[8eic]] - hMDM2 p53-binding domain + catenin + helicon peptide<br /> | ||
**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | **[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | ||
**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | **[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | ||
Current revision
3D structures of MDM2
Updated on 15-December-2025
