9yq0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9yq0 is ON HOLD Authors: Susorov, D., Korostelev, A.A. Description: Vacant ribosome with P-site tRNA, substate 2, Structure Ib [[Category: Unreleas...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Vacant ribosome with P-site tRNA, substate 2, Structure Ib== | |
| - | + | <StructureSection load='9yq0' size='340' side='right'caption='[[9yq0]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9yq0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YQ0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yq0 OCA], [https://pdbe.org/9yq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yq0 RCSB], [https://www.ebi.ac.uk/pdbsum/9yq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yq0 ProSAT]</span></td></tr> |
| - | [[Category: Korostelev | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RL13A_RABIT RL13A_RABIT] Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.[UniProtKB:P40429] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
| + | [[Category: Korostelev AA]] | ||
| + | [[Category: Susorov D]] | ||
Current revision
Vacant ribosome with P-site tRNA, substate 2, Structure Ib
| |||||||||||
