1x8b

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[[Image:1x8b.gif|left|200px]]
[[Image:1x8b.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1x8b |SIZE=350|CAPTION= <scene name='initialview01'>1x8b</scene>, resolution 1.81&Aring;
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The line below this paragraph, containing "STRUCTURE_1x8b", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=824:9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE'>824</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1x8b| PDB=1x8b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x8b OCA], [http://www.ebi.ac.uk/pdbsum/1x8b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x8b RCSB]</span>
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}}
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'''Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824'''
'''Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824'''
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[[Category: Ivanovic, I.]]
[[Category: Ivanovic, I.]]
[[Category: Squire, C J.]]
[[Category: Squire, C J.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: wee1]]
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[[Category: Wee1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:41:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:46:07 2008''
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Revision as of 11:41, 3 May 2008

Image:1x8b.gif

Template:STRUCTURE 1x8b

Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824


Overview

Phosphorylation is critical to regulation of the eukaryotic cell cycle. Entry to mitosis is triggered by the cyclin-dependent kinase CDK1 (Cdc2), which is inactivated during the preceding S and G2 phases by phosphorylation of T14 and Y15. Two homologous kinases, Wee1, which phosphorylates Y15, and Myt1, which phosphorylates both T14 and Y15, mediate this inactivation. We have determined the crystal structure of the catalytic domain of human somatic Wee1 (Wee1A) complexed with an active-site inhibitor at 1.8 A resolution. Although Wee1A is functionally a tyrosine kinase, in sequence and structure it most closely resembles serine/threonine kinases such as Chk1 and cAMP kinases. The crystal structure shows that although the catalytic site closely resembles that of other protein kinases, the activation segment contains Wee1-specific features that maintain it in an active conformation and, together with a key substitution in its glycine-rich loop, help determine its substrate specificity.

About this Structure

1X8B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation., Squire CJ, Dickson JM, Ivanovic I, Baker EN, Structure. 2005 Apr;13(4):541-50. PMID:15837193 Page seeded by OCA on Sat May 3 14:41:49 2008

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