2c7u
From Proteopedia
(New page: 200px<br /> <applet load="2c7u" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c7u, resolution 2.38Å" /> '''CONFLICTING SELECTI...) |
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==Overview== | ==Overview== | ||
Cytotoxic T lymphocytes (CTLs) are critical for the control of human, immunodeficiency virus, but containment of virus replication can be, undermined by mutations in CTL epitopes that lead to virus escape. We, analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL, epitope and found two principal, diametrically opposed evolutionary, pathways that exclusively affect T cell-receptor contact residues. One, pathway was characterized by acquisition of CTL escape mutations and the, other by selection for wild-type amino acids. The pattern of CTL responses, to epitope variants shaped which variant(s) prevailed in the virus, population. The pathways notably influenced the amount of plasma virus, as, patients with efficient CTL selection had lower plasma viral loads than, did patients without efficient selection. Thus, viral escape from CTL, responses does not necessarily correlate with disease progression. | Cytotoxic T lymphocytes (CTLs) are critical for the control of human, immunodeficiency virus, but containment of virus replication can be, undermined by mutations in CTL epitopes that lead to virus escape. We, analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL, epitope and found two principal, diametrically opposed evolutionary, pathways that exclusively affect T cell-receptor contact residues. One, pathway was characterized by acquisition of CTL escape mutations and the, other by selection for wild-type amino acids. The pattern of CTL responses, to epitope variants shaped which variant(s) prevailed in the virus, population. The pathways notably influenced the amount of plasma virus, as, patients with efficient CTL selection had lower plasma viral loads than, did patients without efficient selection. Thus, viral escape from CTL, responses does not necessarily correlate with disease progression. | ||
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| + | ==Disease== | ||
| + | Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Ankylosing spondylitis, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Stevens-Johnson syndrome, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:12:28 2007'' |
Revision as of 19:06, 12 November 2007
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CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.
Contents |
Overview
Cytotoxic T lymphocytes (CTLs) are critical for the control of human, immunodeficiency virus, but containment of virus replication can be, undermined by mutations in CTL epitopes that lead to virus escape. We, analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL, epitope and found two principal, diametrically opposed evolutionary, pathways that exclusively affect T cell-receptor contact residues. One, pathway was characterized by acquisition of CTL escape mutations and the, other by selection for wild-type amino acids. The pattern of CTL responses, to epitope variants shaped which variant(s) prevailed in the virus, population. The pathways notably influenced the amount of plasma virus, as, patients with efficient CTL selection had lower plasma viral loads than, did patients without efficient selection. Thus, viral escape from CTL, responses does not necessarily correlate with disease progression.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
2C7U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope., Iversen AK, Stewart-Jones G, Learn GH, Christie N, Sylvester-Hviid C, Armitage AE, Kaul R, Beattie T, Lee JK, Li Y, Chotiyarnwong P, Dong T, Xu X, Luscher MA, MacDonald K, Ullum H, Klarlund-Pedersen B, Skinhoj P, Fugger L, Buus S, Mullins JI, Jones EY, van der Merwe PA, McMichael AJ, Nat Immunol. 2006 Feb;7(2):179-89. Epub 2006 Jan 1. PMID:16388312
Page seeded by OCA on Mon Nov 12 21:12:28 2007
Categories: Homo sapiens | Protein complex | Armitage, A.E. | Beattie, T. | Buus, S. | Chotiyarnwong, P. | Christie, N. | Dong, T. | Fugger, J.L. | Iversen, A.K. | Jones, E.Y. | Kaul, R. | Klarlund-Pedersen, B. | Learn, G.H. | Lee, J.K. | Li, Y. | Luscher, M.A. | Macdonald, K. | Mcmichael, A.J. | Merwe, P.A.Van.Der. | Mullins, J.I. | Skinhoj, P. | Stewart-Jones, G. | Sylvester-Hviid, C. | Ullum, H. | Xu, X. | Aids | Glycoprotein | Glycoprotein/peptide complex | Hiv | Hla-a2 | Immune response | Immunoglobulin domain | Mhc | Mhc i | Polymorphism | Pyrrolidone carboxylic acid | Tcr | Transmembrane
