1yw2

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[[Image:1yw2.gif|left|200px]]
[[Image:1yw2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yw2 |SIZE=350|CAPTION= <scene name='initialview01'>1yw2</scene>, resolution 2.01&Aring;
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The line below this paragraph, containing "STRUCTURE_1yw2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PGJ:2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE'>PGJ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1yw2| PDB=1yw2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yw2 OCA], [http://www.ebi.ac.uk/pdbsum/1yw2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yw2 RCSB]</span>
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}}
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'''Mutated Mus Musculus P38 Kinase (mP38)'''
'''Mutated Mus Musculus P38 Kinase (mP38)'''
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[[Category: Walter, R L.]]
[[Category: Walter, R L.]]
[[Category: Xu, S C.]]
[[Category: Xu, S C.]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:51:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:24:41 2008''
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Revision as of 13:51, 3 May 2008

Image:1yw2.gif

Template:STRUCTURE 1yw2

Mutated Mus Musculus P38 Kinase (mP38)


Overview

4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.

About this Structure

1YW2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production., Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. PMID:15837333 Page seeded by OCA on Sat May 3 16:51:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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