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1yx6

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[[Image:1yx6.gif|left|200px]]
[[Image:1yx6.gif|left|200px]]
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{{Structure
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|GENE= PSMD4, MCB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1yx6| PDB=1yx6 | SCENE= }}
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|RELATEDENTRY=[[1d3z|1D3Z]], [[1tbe|1TBE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx6 OCA], [http://www.ebi.ac.uk/pdbsum/1yx6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yx6 RCSB]</span>
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'''Solution Structure of S5a UIM-2/Ubiquitin Complex'''
'''Solution Structure of S5a UIM-2/Ubiquitin Complex'''
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[[Category: Wang, Q.]]
[[Category: Wang, Q.]]
[[Category: Young, P.]]
[[Category: Young, P.]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: polyubiquitin]]
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[[Category: Polyubiquitin]]
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[[Category: proteasome]]
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[[Category: Proteasome]]
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[[Category: s5a]]
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[[Category: S5a]]
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[[Category: uim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:54:42 2008''
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Revision as of 13:54, 3 May 2008

Image:1yx6.gif

Template:STRUCTURE 1yx6

Solution Structure of S5a UIM-2/Ubiquitin Complex


Overview

Ubiquitin is a key regulatory molecule in diverse cellular events. How cells determine the outcome of ubiquitylation remains unclear; however, a likely determinant is the specificity of ubiquitin receptor proteins for polyubiquitin chains of certain length and linkage. Proteasome subunit S5a contains two ubiquitin-interacting motifs (UIMs) through which it recruits ubiquitylated substrates to the proteasome for their degradation. Here, we report the structure of S5a (196-306) alone and complexed with two monoubiquitin molecules. This construct contains the two UIMs of S5a and we reveal their different ubiquitin-binding mechanisms and provide a rationale for their unique specificities for different ubiquitin-like domains. Furthermore, we provide direct evidence that S5a (196-306) binds either K63-linked or K48-linked polyubiquitin, and in both cases prefers longer chains. On the basis of these results we present a model for how S5a and other ubiquitin-binding proteins recognize polyubiquitin.

About this Structure

1YX6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition., Wang Q, Young P, Walters KJ, J Mol Biol. 2005 May 6;348(3):727-39. PMID:15826667 Page seeded by OCA on Sat May 3 16:54:42 2008

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