1z4z

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[[Image:1z4z.gif|left|200px]]
[[Image:1z4z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z4z |SIZE=350|CAPTION= <scene name='initialview01'>1z4z</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_1z4z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5])
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-->
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|DOMAIN=
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{{STRUCTURE_1z4z| PDB=1z4z | SCENE= }}
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|RELATEDENTRY=[[1z4v|1Z4V]], [[1z4x|1Z4X]], [[1z4w|1Z4W]], [[1z4y|1Z4Y]], [[1z50|1Z50]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4z OCA], [http://www.ebi.ac.uk/pdbsum/1z4z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z4z RCSB]</span>
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}}
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'''Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))'''
'''Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))'''
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[[Category: Wurzburg, B A.]]
[[Category: Wurzburg, B A.]]
[[Category: Yuan, P.]]
[[Category: Yuan, P.]]
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[[Category: hemagglutinin,neuraminidase,fusion,tetramer]]
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[[Category: Hemagglutinin,neuraminidase,fusion,tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:10 2008''
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Revision as of 14:11, 3 May 2008

Image:1z4z.gif

Template:STRUCTURE 1z4z

Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))


Overview

The paramyxovirus hemagglutinin-neuraminidase (HN) functions in virus attachment to cells, cleavage of sialic acid from oligosaccharides, and stimulating membrane fusion during virus entry into cells. The structural basis for these diverse functions remains to be fully understood. We report the crystal structures of the parainfluenza virus 5 (SV5) HN and its complexes with sialic acid, the inhibitor DANA, and the receptor sialyllactose. SV5 HN shares common structural features with HN of Newcastle disease virus (NDV) and human parainfluenza 3 (HPIV3), but unlike the previously determined HN structures, the SV5 HN forms a tetramer in solution, which is thought to be the physiological oligomer. The sialyllactose complex reveals intact receptor within the active site, but no major conformational changes in the protein. The SV5 HN structures do not support previously proposed models for HN action in membrane fusion and suggest alternative mechanisms by which HN may promote virus entry into cells.

About this Structure

1Z4Z is a Single protein structure of sequence from Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:15893670 Page seeded by OCA on Sat May 3 17:11:03 2008

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OCA

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