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1z53

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[[Image:1z53.gif|left|200px]]
[[Image:1z53.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z53 |SIZE=350|CAPTION= <scene name='initialview01'>1z53</scene>, resolution 1.13&Aring;
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The line below this paragraph, containing "STRUCTURE_1z53", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PP9:PROTOPORPHYRIN+IX'>PP9</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CCP1, CCP, CPO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1z53| PDB=1z53 | SCENE= }}
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|RELATEDENTRY=[[2cyp|2CYP]], [[1kok|1KOK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z53 OCA], [http://www.ebi.ac.uk/pdbsum/1z53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z53 RCSB]</span>
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}}
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'''The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase'''
'''The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase'''
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[[Category: Bhaskar, B.]]
[[Category: Bhaskar, B.]]
[[Category: Poulos, T L.]]
[[Category: Poulos, T L.]]
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[[Category: ccp]]
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[[Category: Ccp]]
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[[Category: heme peroxidase]]
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[[Category: Heme peroxidase]]
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[[Category: iron-free protoporphyrin ix]]
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[[Category: Iron-free protoporphyrin ix]]
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[[Category: trp cation radical]]
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[[Category: Trp cation radical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:11 2008''
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Revision as of 14:11, 3 May 2008

Image:1z53.gif

Template:STRUCTURE 1z53

The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase


Overview

The iron-free cytochrome c peroxidase (CCP) crystal structure has been determined to 1.13 A and compared with the 1.2-A ferric-CCP structure. Quite unexpectedly, removal of the iron has no effect on porphyrin geometry and distortion, indicating that protein-porphyrin interactions and not iron coordination or formation of the axial His-Fe bond determines porphyrin conformation. However, there are changes in solvent structure in the distal pocket, which lead to changes in the distal His52 acid-base catalyst. The observed ability of His52 to move in response to small changes in solvent structure is very likely important for its role as a catalyst in assisting in the heterolytic fission of the peroxide O-O bond.

About this Structure

1Z53 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The 1.13-A structure of iron-free cytochrome c peroxidase., Bhaskar B, Poulos TL, J Biol Inorg Chem. 2005 Jun;10(4):425-30. Epub 2005 May 18. PMID:15900441 Page seeded by OCA on Sat May 3 17:11:07 2008

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