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1z77
From Proteopedia
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'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.''' | '''Crystal structure of transcriptional regulator protein from Thermotoga maritima.''' | ||
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[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
[[Category: Zimmerman, M D.]] | [[Category: Zimmerman, M D.]] | ||
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| - | [[Category: | + | [[Category: Midwest center for structural genomic]] |
| - | [[Category: | + | [[Category: Protein structure initiative]] |
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| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Tetr family]] |
| - | [[Category: | + | [[Category: Transcriptional regulator]] |
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Revision as of 14:15, 3 May 2008
Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Overview
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
About this Structure
1Z77 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774 Page seeded by OCA on Sat May 3 17:15:52 2008
Categories: Single protein | Thermotoga maritima | Chruszcz, M. | Cymborowski, M. | Koclega, K D. | Kudritska, M. | MCSG, Midwest Center for Structural Genomics. | Minor, W. | Zimmerman, M D. | Mcsg | Midwest center for structural genomic | Protein structure initiative | Psi | Structural genomic | Tetr family | Transcriptional regulator
