1zap

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[[Image:1zap.gif|left|200px]]
[[Image:1zap.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zap |SIZE=350|CAPTION= <scene name='initialview01'>1zap</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1zap", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACT:Aspartic+Proteinases+Are+Characterized+By+Two+ASP+Residu+...'>ACT</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A70:(2S)-2-[(3R)-3-BENZYL-4-N-(4-METHYLPIPERAZIN-1-YL-CARBONYL)2-KETOPIPERAZIN-1-YL]-HEXANOIC+ACID+AMIDE+OF+(2R,4S,5S)-5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISO-PROPYLHEXANOYL+N-(N-AMIDE)'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1zap| PDB=1zap | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB]</span>
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}}
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'''SECRETED ASPARTIC PROTEASE FROM C. ALBICANS'''
'''SECRETED ASPARTIC PROTEASE FROM C. ALBICANS'''
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[[Category: Abad-Zapatero, C.]]
[[Category: Abad-Zapatero, C.]]
[[Category: Muchmore, S W.]]
[[Category: Muchmore, S W.]]
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[[Category: aspartic protease]]
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[[Category: Aspartic protease]]
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[[Category: candida albican]]
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[[Category: Candida albican]]
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[[Category: secreted]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:23:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:33:14 2008''
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Revision as of 14:23, 3 May 2008

Image:1zap.gif

Template:STRUCTURE 1zap

SECRETED ASPARTIC PROTEASE FROM C. ALBICANS


Overview

The three-dimensional structure of a secreted aspartic protease from Candida albicans complexed with a potent inhibitor reveals variations on the classical aspartic protease theme that dramatically alter the specificity of this class of enzymes. The structure presents: (1) an 8-residue insertion near the first disulfide (Cys 45-Cys 50, pepsin numbering) that results in a broad flap extending toward the active site; (2) a 7-residue deletion replacing helix hN2 (Ser 110-Tyr 114), which enlarges the S3 pocket; (3) a short polar connection between the two rigid body domains that alters their relative orientation and provides certain specificity; and (4) an ordered 11-residue addition at the carboxy terminus. The inhibitor binds in an extended conformation and presents a branched structure at the P3 position. The implications of these findings for the design of potent antifungal agents are discussed.

About this Structure

1ZAP is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents., Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL, Protein Sci. 1996 Apr;5(4):640-52. PMID:8845753 Page seeded by OCA on Sat May 3 17:23:51 2008

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OCA

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