1zc8

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[[Image:1zc8.gif|left|200px]]
[[Image:1zc8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zc8 |SIZE=350|CAPTION= <scene name='initialview01'>1zc8</scene>
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The line below this paragraph, containing "STRUCTURE_1zc8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1zc8| PDB=1zc8 | SCENE= }}
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|RELATEDENTRY=[[1k8h|1K8H]], [[1b23|1B23]], [[1n32|1N32]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc8 OCA], [http://www.ebi.ac.uk/pdbsum/1zc8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zc8 RCSB]</span>
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}}
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'''Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex'''
'''Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex'''
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==About this Structure==
==About this Structure==
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1ZC8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC8 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC8 OCA].
==Reference==
==Reference==
Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12677067 12677067]
Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12677067 12677067]
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[[Category: Protein complex]]
 
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[[Category: Thermus thermophilus]]
 
[[Category: Frank, J.]]
[[Category: Frank, J.]]
[[Category: Gillet, R.]]
[[Category: Gillet, R.]]
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[[Category: 30]]
[[Category: 30]]
[[Category: 70]]
[[Category: 70]]
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[[Category: cryo-em]]
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[[Category: Cryo-em]]
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[[Category: ef-tu]]
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[[Category: Ef-tu]]
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[[Category: h44]]
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[[Category: H44]]
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[[Category: smpb]]
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[[Category: Smpb]]
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[[Category: tmrna]]
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[[Category: Tmrna]]
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[[Category: trans-translation]]
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[[Category: Trans-translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:27:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:33:52 2008''
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Revision as of 14:27, 3 May 2008

Image:1zc8.gif

Template:STRUCTURE 1zc8

Coordinates of tmRNA, SmpB, EF-Tu and h44 fitted into Cryo-EM map of the 70S ribosome and tmRNA complex


Overview

Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an approximately 300-nucleotide-long molecule that functions as both transfer RNA (tRNA) and mRNA. Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation. However, the mechanism by which tmRNA can enter and move through the ribosome is unknown. We present a cryo-electron microscopy study at approximately 13 to 15 angstroms of the entry of tmRNA into the ribosome. The structure reveals how tmRNA could move through the ribosome despite its complicated topology and also suggests roles for proteins S1 and SmpB in the function of tmRNA.

About this Structure

Full crystallographic information is available from OCA.

Reference

Visualizing tmRNA entry into a stalled ribosome., Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J, Science. 2003 Apr 4;300(5616):127-30. PMID:12677067 Page seeded by OCA on Sat May 3 17:27:04 2008

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