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244d

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[[Image:244d.jpg|left|200px]]
[[Image:244d.jpg|left|200px]]
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{{Structure
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|PDB= 244d |SIZE=350|CAPTION= <scene name='initialview01'>244d</scene>, resolution 1.200&Aring;
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The line below this paragraph, containing "STRUCTURE_244d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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{{STRUCTURE_244d| PDB=244d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.ebi.ac.uk/pdbsum/244d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB]</span>
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'''THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX'''
'''THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX'''
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==About this Structure==
==About this Structure==
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244D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA].
==Reference==
==Reference==
The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8036494 8036494]
The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8036494 8036494]
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[[Category: Protein complex]]
 
[[Category: Laughlan, G.]]
[[Category: Laughlan, G.]]
[[Category: Lilley, D M.J.]]
[[Category: Lilley, D M.J.]]
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[[Category: Murchie, A I.H.]]
[[Category: Murchie, A I.H.]]
[[Category: Norman, D G.]]
[[Category: Norman, D G.]]
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[[Category: parallel-stranded tetraplex]]
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[[Category: Parallel-stranded tetraplex]]
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[[Category: quadruple helix]]
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[[Category: Quadruple helix]]
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[[Category: unusual dna]]
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[[Category: Unusual dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:22:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:06 2008''
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Revision as of 15:22, 3 May 2008

Image:244d.jpg

Template:STRUCTURE 244d

THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX


Overview

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.

About this Structure

Full crystallographic information is available from OCA.

Reference

The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:8036494 Page seeded by OCA on Sat May 3 18:22:27 2008

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