2aa3
From Proteopedia
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'''Crystal structure of Plasmodium vivax lactate dehydrogenase complex with APADH''' | '''Crystal structure of Plasmodium vivax lactate dehydrogenase complex with APADH''' | ||
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[[Category: Joseph-Horne, T.]] | [[Category: Joseph-Horne, T.]] | ||
[[Category: Turgut-Balik, D.]] | [[Category: Turgut-Balik, D.]] | ||
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Revision as of 15:48, 3 May 2008
Crystal structure of Plasmodium vivax lactate dehydrogenase complex with APADH
Overview
Malaria caused by Plasmodium vivax is a major cause of global morbidity and, in rare cases, mortality. Lactate dehydrogenase is an essential Plasmodium protein and, therefore, a potential antimalarial drug target. Ideally, drugs directed against this target would be effective against both major species of Plasmodium, P. falciparum and P. vivax. In this study, the crystal structure of the lactate dehydrogenase protein from P. vivax has been solved and is compared to the equivalent structure from the P. falciparum enzyme. The active sites and cofactor binding pockets of both enzymes are found to be highly similar and differentiate these enzymes from their human counterparts. These structures suggest effective inhibition of both enzymes should be readily achievable with a common inhibitor. The crystal structures of both enzymes have also been solved in complex with the synthetic cofactor APADH. The unusual cofactor binding site in these Plasmodium enzymes is found to readily accommodate both NADH and APADH, explaining why the Plasmodium enzymes retain enzymatic activity in the presence of this synthetic cofactor.
About this Structure
2AA3 is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.
Reference
Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH., Chaikuad A, Fairweather V, Conners R, Joseph-Horne T, Turgut-Balik D, Brady RL, Biochemistry. 2005 Dec 13;44(49):16221-8. PMID:16331982 Page seeded by OCA on Sat May 3 18:48:01 2008
