2as0

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[[Image:2as0.gif|left|200px]]
[[Image:2as0.gif|left|200px]]
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{{Structure
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|PDB= 2as0 |SIZE=350|CAPTION= <scene name='initialview01'>2as0</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2as0", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= PH1915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02475 Met_10], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1092 COG1092], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00359 PUA]</span>
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{{STRUCTURE_2as0| PDB=2as0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2as0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2as0 OCA], [http://www.ebi.ac.uk/pdbsum/2as0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2as0 RCSB]</span>
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'''Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase'''
'''Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase'''
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[[Category: Sun, W.]]
[[Category: Sun, W.]]
[[Category: Xu, X.]]
[[Category: Xu, X.]]
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[[Category: Mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: Midwest center for structural genomic]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: rna methyltransferase]]
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[[Category: Rna methyltransferase]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:24:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:56:31 2008''
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Revision as of 16:24, 3 May 2008

Image:2as0.gif

Template:STRUCTURE 2as0

Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase


Overview

The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.

About this Structure

2AS0 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:16260766 Page seeded by OCA on Sat May 3 19:24:26 2008

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