2b4n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2b4n.gif|left|200px]]
[[Image:2b4n.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2b4n |SIZE=350|CAPTION= <scene name='initialview01'>2b4n</scene>
+
The line below this paragraph, containing "STRUCTURE_2b4n", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2b4n| PDB=2b4n | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4n OCA], [http://www.ebi.ac.uk/pdbsum/2b4n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b4n RCSB]</span>
+
-
}}
+
'''Solution Structure of Glucose-Dependent Insulinotropic Polypeptide'''
'''Solution Structure of Glucose-Dependent Insulinotropic Polypeptide'''
Line 29: Line 26:
[[Category: Hewage, C M.]]
[[Category: Hewage, C M.]]
[[Category: Malthouse, J P.G.]]
[[Category: Malthouse, J P.G.]]
-
[[Category: diabetes]]
+
[[Category: Diabetes]]
-
[[Category: gip]]
+
[[Category: Gip]]
-
[[Category: helix]]
+
[[Category: Helix]]
-
[[Category: molecular modelling]]
+
[[Category: Molecular modelling]]
-
[[Category: nmr]]
+
[[Category: Nmr]]
-
[[Category: obesity]]
+
[[Category: Obesity]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:02 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:22 2008''
+

Revision as of 16:51, 3 May 2008

Image:2b4n.gif

Template:STRUCTURE 2b4n

Solution Structure of Glucose-Dependent Insulinotropic Polypeptide


Overview

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates the secretion of insulin after ingestion of food. GIP also promotes the synthesis of fatty acids in adipose tissue. Therefore, it is not surprising that numerous literature reports have shown that GIP is linked to diabetes and obesity-related diseases. In this study, we present the solution structure of GIP in water determined by NMR spectroscopy. The calculated structure is characterized by the presence of an alpha-helical motif between residues Ser(11) and Gln(29). The helical conformation of GIP is further supported by CD spectroscopic studies. Six GIP-(1-42)Ala(1-7) analogues were synthesized by replacing individual N-terminal residues with alanine. Alanine scan studies of these N-terminal residues showed that the GIP-(1-42)Ala(6) was the only analogue to show insulin-secreting activity similar to that of the native GIP. However, when compared with glucose, its insulinotropic ability was reduced. For the first time, these NMR and modeling results contribute to the understanding of the structural requirements for the biological activity of GIP.

About this Structure

2B4N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water., Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM, J Biol Chem. 2006 Jun 16;281(24):16370-6. Epub 2006 Apr 18. PMID:16621806 Page seeded by OCA on Sat May 3 19:51:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b4n"
Personal tools