2bex

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[[Image:2bex.gif|left|200px]]
[[Image:2bex.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bex |SIZE=350|CAPTION= <scene name='initialview01'>2bex</scene>, resolution 1.99&Aring;
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The line below this paragraph, containing "STRUCTURE_2bex", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mak+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAK:ALPHA-KETOMALONIC+ACID'>MAK</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2bex| PDB=2bex | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bex OCA], [http://www.ebi.ac.uk/pdbsum/2bex PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bex RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION'''
'''CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION'''
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[[Category: Kumar, K.]]
[[Category: Kumar, K.]]
[[Category: Shapiro, R.]]
[[Category: Shapiro, R.]]
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[[Category: eosinophil derived neurotoxin]]
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[[Category: Eosinophil derived neurotoxin]]
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[[Category: luecine-rich repeat]]
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[[Category: Luecine-rich repeat]]
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[[Category: molecular recognition]]
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[[Category: Molecular recognition]]
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[[Category: protein-protein interaction]]
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[[Category: Protein-protein interaction]]
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[[Category: ribonuclease inhibitor]]
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[[Category: Ribonuclease inhibitor]]
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[[Category: rnase 2]]
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[[Category: Rnase 2]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:11:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:05:24 2008''
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Revision as of 17:11, 3 May 2008

Image:2bex.gif

Template:STRUCTURE 2bex

CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION


Overview

Placental ribonuclease inhibitor (RI) binds diverse mammalian RNases with dissociation constants that are in the femtomolar range. Previous studies on the complexes of RI with RNase A and angiogenin revealed that RI utilises largely distinctive interactions to achieve high affinity for these two ligands. Here we report a 2.0 angstroms resolution crystal structure of RI in complex with a third ligand, eosinophil-derived neurotoxin (EDN), and a mutational analysis based on this structure. The RI-EDN interface is more extensive than those of the other two complexes and contains a considerably larger set of interactions. Few of the contacts present in the RI-angiogenin complex are replicated; the correspondence to the RI-RNase A complex is somewhat greater, but still modest. The energetic contributions of various interface regions differ strikingly from those in the earlier complexes. These findings provide insight into the structural basis for the unusual combination of high avidity and relaxed stringency that RI displays.

About this Structure

2BEX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor., Iyer S, Holloway DE, Kumar K, Shapiro R, Acharya KR, J Mol Biol. 2005 Apr 1;347(3):637-55. PMID:15755456 Page seeded by OCA on Sat May 3 20:11:58 2008

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