2boo

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[[Image:2boo.gif|left|200px]]
[[Image:2boo.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2boo |SIZE=350|CAPTION= <scene name='initialview01'>2boo</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2boo", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:No3+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2boo| PDB=2boo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boo OCA], [http://www.ebi.ac.uk/pdbsum/2boo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2boo RCSB]</span>
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}}
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'''THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.'''
'''THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.'''
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[[Category: Moe, E.]]
[[Category: Moe, E.]]
[[Category: Smalas, A O.]]
[[Category: Smalas, A O.]]
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[[Category: base excision repair]]
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[[Category: Base excision repair]]
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[[Category: deinococcus radioduran]]
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[[Category: Deinococcus radioduran]]
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[[Category: dna damage]]
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[[Category: Dna damage]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: glycosidase]]
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[[Category: Glycosidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: radiation resistance]]
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[[Category: Radiation resistance]]
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[[Category: ung]]
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[[Category: Ung]]
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[[Category: uracil-dna glycosylase]]
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[[Category: Uracil-dna glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:35:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:27 2008''
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Revision as of 17:35, 3 May 2008

Image:2boo.gif

Template:STRUCTURE 2boo

THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.


Overview

Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U-A or U-G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported.

About this Structure

2BOO is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans., Leiros I, Moe E, Smalas AO, McSweeney S, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1049-56. Epub 2005, Jul 20. PMID:16041069 Page seeded by OCA on Sat May 3 20:35:07 2008

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OCA

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