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2bz5
From Proteopedia
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[[Image:2bz5.gif|left|200px]] | [[Image:2bz5.gif|left|200px]] | ||
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'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS''' | '''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS''' | ||
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[[Category: Surgenor, A.]] | [[Category: Surgenor, A.]] | ||
[[Category: Wright, L.]] | [[Category: Wright, L.]] | ||
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| - | [[Category: | + | [[Category: Nucleotide-binding]] |
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:06 2008'' | |
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Revision as of 18:00, 3 May 2008
STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS
Overview
Docking-based virtual screening identified 1-(2-phenol)-2-naphthol compounds as a new class of Hsp90 inhibitors of low to sub-micromolar potency. Here we report the binding affinities and cellular activities of several members of this class. A high resolution crystal structure of the most potent compound reveals its binding mode in the ATP binding site of Hsp90, providing a rationale for the observed activity of the series and suggesting strategies for developing compounds with improved properties.
About this Structure
2BZ5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based discovery of a new class of Hsp90 inhibitors., Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. Epub 2005 Oct 3. PMID:16202589 Page seeded by OCA on Sat May 3 21:00:06 2008
