2c1v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2c1v.gif|left|200px]]
[[Image:2c1v.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2c1v |SIZE=350|CAPTION= <scene name='initialview01'>2c1v</scene>, resolution 1.20&Aring;
+
The line below this paragraph, containing "STRUCTURE_2c1v", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2c1v| PDB=2c1v | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1v OCA], [http://www.ebi.ac.uk/pdbsum/2c1v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c1v RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE DI-HAEM CYTOCHROME C PEROXIDASE FROM PARACOCCUS PANTOTROPHUS- MIXED VALENCE FORM'''
'''CRYSTAL STRUCTURE OF THE DI-HAEM CYTOCHROME C PEROXIDASE FROM PARACOCCUS PANTOTROPHUS- MIXED VALENCE FORM'''
Line 28: Line 25:
[[Category: Echalier, A.]]
[[Category: Echalier, A.]]
[[Category: Fulop, V.]]
[[Category: Fulop, V.]]
-
[[Category: electron transport]]
+
[[Category: Electron transport]]
-
[[Category: heme]]
+
[[Category: Heme]]
-
[[Category: oxidoreductase,periplasmic]]
+
[[Category: Oxidoreductase,periplasmic]]
-
[[Category: peroxidase]]
+
[[Category: Peroxidase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:07:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:15:02 2008''
+

Revision as of 18:07, 3 May 2008

Image:2c1v.gif

Template:STRUCTURE 2c1v

CRYSTAL STRUCTURE OF THE DI-HAEM CYTOCHROME C PEROXIDASE FROM PARACOCCUS PANTOTROPHUS- MIXED VALENCE FORM


Overview

Bacterial cytochrome c peroxidases contain an electron transferring (E) heme domain and a peroxidatic (P) heme domain. All but one of these enzymes are isolated in an inactive oxidized state and require reduction of the E heme by a small redox donor protein in order to activate the P heme. Here we present the structures of the inactive oxidized and active mixed valence enzyme from Paracoccus pantotrophus. Chain flexibility in the former, as expressed by the crystallographic temperature factors, is strikingly distributed in certain loop regions, and these coincide with the regions of conformational change that occur in forming the active mixed valence enzyme. On the basis of these changes, we postulate a series of events that occur to link the trigger of the electron entering the E heme from either pseudoazurin or cytochrome c(550) and the dissociation of a coordinating histidine at the P heme, which allows substrate access.

About this Structure

2C1V is a Single protein structure of sequence from Paracoccus pantotrophus. Full crystallographic information is available from OCA.

Reference

Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus., Echalier A, Goodhew CF, Pettigrew GW, Fulop V, Structure. 2006 Jan;14(1):107-17. PMID:16407070 Page seeded by OCA on Sat May 3 21:07:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c1v"
Personal tools