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2c7m

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[[Image:2c7m.gif|left|200px]]
[[Image:2c7m.gif|left|200px]]
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{{Structure
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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{{STRUCTURE_2c7m| PDB=2c7m | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7m OCA], [http://www.ebi.ac.uk/pdbsum/2c7m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c7m RCSB]</span>
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'''HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN'''
'''HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN'''
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[[Category: Polo, S.]]
[[Category: Polo, S.]]
[[Category: Schneider, T R.]]
[[Category: Schneider, T R.]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: polyprotein]]
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[[Category: Polyprotein]]
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[[Category: ubiquitin binding domain]]
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[[Category: Ubiquitin binding domain]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:23:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:17:32 2008''
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Revision as of 18:23, 3 May 2008

Image:2c7m.gif

Template:STRUCTURE 2c7m

HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN


Overview

The interaction between ubiquitinated proteins and intracellular proteins harboring ubiquitin binding domains (UBDs) is critical to a multitude of cellular processes. Here, we report that Rabex-5, a guanine nucleotide exchange factor for Rab5, binds to Ub through two independent UBDs. These UBDs determine a number of properties of Rabex-5, including its coupled monoubiquitination and interaction in vivo with ubiquitinated EGFRs. Structural and biochemical characterization of the UBDs of Rabex-5 revealed that one of them (MIU, motif interacting with ubiquitin) binds to Ub with modes superimposable to those of the UIM (ubiquitin-interacting motif):Ub interaction, although in the opposite orientation. The other UBD, RUZ (Rabex-5 ubiquitin binding zinc finger) binds to a surface of Ub centered on Asp58(Ub) and distinct from the "canonical" Ile44(Ub)-based surface. The two binding surfaces allow Ub to interact simultaneously with different UBDs, thus opening new perspectives in Ub-mediated signaling.

About this Structure

2C7M is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin., Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR, Cell. 2006 Mar 24;124(6):1183-95. Epub 2006 Feb 23. PMID:16499958 Page seeded by OCA on Sat May 3 21:23:24 2008

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