2cii

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[[Image:2cii.gif|left|200px]]
[[Image:2cii.gif|left|200px]]
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{{Structure
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|PDB= 2cii |SIZE=350|CAPTION= <scene name='initialview01'>2cii</scene>, resolution 2.55&Aring;
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The line below this paragraph, containing "STRUCTURE_2cii", creates the "Structure Box" on the page.
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{{STRUCTURE_2cii| PDB=2cii | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE'''
'''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE'''
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[[Category: Kojima, M.]]
[[Category: Kojima, M.]]
[[Category: Tormo, J.]]
[[Category: Tormo, J.]]
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[[Category: complex (antigen/peptide)]]
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[[Category: Glycoprotein]]
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[[Category: glycoprotein]]
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[[Category: Immune response]]
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[[Category: immune response]]
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[[Category: Immunoglobulin domain]]
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[[Category: immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: membrane]]
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[[Category: Mhc class i]]
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[[Category: mhc class i]]
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[[Category: Mhc i]]
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[[Category: mhc i]]
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[[Category: Peptide binding]]
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[[Category: peptide binding]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: Sendai virus]]
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[[Category: sendai virus]]
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[[Category: Transmembrane]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:13:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:59 2008''
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Revision as of 19:13, 3 May 2008

Image:2cii.gif

Template:STRUCTURE 2cii

THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE


Overview

In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilization, we have used short synthetic peptides derived from the Sendai virus nucleoprotein epitope (residues 324-332, 1FAPGNYPAL9) to promote its folding in vitro of H-2D(b). We found that H-2D(b) can be stabilized by the pentapeptide 5NYPAL9, which is equivalent to the C-terminal portion of the optimal nonapeptide and includes both the P5 and P9 anchor residues. We have crystallized the complex of the H-2D(b) molecule with the pentamer and determined the structure to show how a quasi-stable MHC class I molecule can be formed by occupancy of a single binding pocket in the peptide-binding groove.

About this Structure

2CII is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate., Glithero A, Tormo J, Doering K, Kojima M, Jones EY, Elliott T, J Biol Chem. 2006 May 5;281(18):12699-704. Epub 2006 Feb 14. PMID:16478731 Page seeded by OCA on Sat May 3 22:13:21 2008

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OCA

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