2dfe
From Proteopedia
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[[Image:2dfe.jpg|left|200px]] | [[Image:2dfe.jpg|left|200px]] | ||
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'''Crystal structure of Tk-RNase HII(1-200)-C''' | '''Crystal structure of Tk-RNase HII(1-200)-C''' | ||
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[[Category: Matsumura, H.]] | [[Category: Matsumura, H.]] | ||
[[Category: Takano, K.]] | [[Category: Takano, K.]] | ||
| - | [[Category: | + | [[Category: Chameleon sequence]] |
| - | [[Category: | + | [[Category: Fusion protein]] |
| - | [[Category: | + | [[Category: Ribonuclease hii]] |
| - | [[Category: | + | [[Category: Thermococcus kodakaraensis]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:19:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:19, 3 May 2008
Crystal structure of Tk-RNase HII(1-200)-C
Overview
Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
About this Structure
2DFE is a Single protein structure of sequence from Thermococcus kodakarensis. Full crystallographic information is available from OCA.
Reference
Conformational contagion in a protein: structural properties of a chameleon sequence., Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S, Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955 Page seeded by OCA on Sun May 4 00:19:05 2008
