2dsk

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[[Image:2dsk.jpg|left|200px]]
[[Image:2dsk.jpg|left|200px]]
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{{Structure
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|PDB= 2dsk |SIZE=350|CAPTION= <scene name='initialview01'>2dsk</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2dsk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2dsk| PDB=2dsk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsk OCA], [http://www.ebi.ac.uk/pdbsum/2dsk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dsk RCSB]</span>
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}}
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'''Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus'''
'''Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus'''
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[[Category: Nakamura, T.]]
[[Category: Nakamura, T.]]
[[Category: Uegaki, K.]]
[[Category: Uegaki, K.]]
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[[Category: active domain]]
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[[Category: Active domain]]
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[[Category: catalytic domain]]
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[[Category: Catalytic domain]]
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[[Category: chitinase]]
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[[Category: Chitinase]]
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[[Category: crystalline chitin]]
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[[Category: Crystalline chitin]]
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[[Category: tim-barrel]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:09:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:38:55 2008''
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Revision as of 22:09, 3 May 2008

Image:2dsk.jpg

Template:STRUCTURE 2dsk

Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus


Overview

The crystal structure of the catalytic domain of a chitinase from the hyperthermophilic archaeon Pyrococcus furiosus (AD2(PF-ChiA)) has been determined at 1.5 A resolution. This is the first structure of the catalytic domain of an archaeal chitinase. The overall structure of AD2(PF-ChiA) is a TIM-barrel fold with a tunnel-like active site that is a common feature of family 18 chitinases. Although the catalytic residues (Asp522, Asp524 and Glu526) are conserved, comparison of the conserved residues and structures with those of other homologous chitinases indicates that the catalytic mechanism of PF-ChiA is different from that of family 18 chitinases.

About this Structure

2DSK is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus., Nakamura T, Mine S, Hagihara Y, Ishikawa K, Uegaki K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt, 1):7-11. Epub 2006 Dec 16. PMID:17183162 Page seeded by OCA on Sun May 4 01:09:07 2008

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