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2fbe
From Proteopedia
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[[Image:2fbe.gif|left|200px]] | [[Image:2fbe.gif|left|200px]] | ||
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'''Crystal Structure of the PRYSPRY-domain''' | '''Crystal Structure of the PRYSPRY-domain''' | ||
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[[Category: Gruetter, M G.]] | [[Category: Gruetter, M G.]] | ||
[[Category: Mittl, P R.]] | [[Category: Mittl, P R.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:41:33 2008'' | |
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Revision as of 00:41, 4 May 2008
Crystal Structure of the PRYSPRY-domain
Overview
We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.
About this Structure
2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311 Page seeded by OCA on Sun May 4 03:41:33 2008
