2g7c

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[[Image:2g7c.gif|left|200px]]
[[Image:2g7c.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2g7c |SIZE=350|CAPTION= <scene name='initialview01'>2g7c</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2g7c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= toxA, tcdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 Clostridium difficile])
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-->
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|DOMAIN=
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{{STRUCTURE_2g7c| PDB=2g7c | SCENE= }}
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|RELATEDENTRY=[[2f6e|2F6E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7c OCA], [http://www.ebi.ac.uk/pdbsum/2g7c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g7c RCSB]</span>
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}}
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'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''
'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''
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[[Category: Palcic, M M.]]
[[Category: Palcic, M M.]]
[[Category: Rupnik, M.]]
[[Category: Rupnik, M.]]
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[[Category: bacterial toxin]]
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[[Category: Bacterial toxin]]
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[[Category: linear b trisaccharide]]
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[[Category: Linear b trisaccharide]]
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[[Category: protein-carbohydrate complex]]
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[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:46:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:50 2008''
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Revision as of 01:46, 4 May 2008

Image:2g7c.gif

Template:STRUCTURE 2g7c

Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc


Overview

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

About this Structure

2G7C is a Single protein structure of sequence from Clostridium difficile. Full crystallographic information is available from OCA.

Reference

Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409 Page seeded by OCA on Sun May 4 04:46:26 2008

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