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2gsq

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[[Image:2gsq.jpg|left|200px]]
[[Image:2gsq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2gsq |SIZE=350|CAPTION= <scene name='initialview01'>2gsq</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2gsq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GBI:S-(3-IODOBENZYL)GLUTATHIONE'>GBI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDNA INSERT OF CLONE PGST5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6633 Ommastrephes sloani])
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-->
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|DOMAIN=
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{{STRUCTURE_2gsq| PDB=2gsq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsq OCA], [http://www.ebi.ac.uk/pdbsum/2gsq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gsq RCSB]</span>
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}}
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'''GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE'''
'''GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE'''
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[[Category: Gilliland, G L.]]
[[Category: Gilliland, G L.]]
[[Category: Ji, X.]]
[[Category: Ji, X.]]
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[[Category: sigma class]]
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[[Category: Sigma class]]
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[[Category: squid digestive gland]]
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[[Category: Squid digestive gland]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:29:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:03 2008''
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Revision as of 02:29, 4 May 2008

Image:2gsq.jpg

Template:STRUCTURE 2gsq

GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE


Overview

The crystal structure of the sigma class glutathione transferase from squid digestive gland in complex with S-(3-iodobenzyl)glutathione reveals a third binding site for the glutathione conjugate besides the two in the active sites of the dimer. The additional binding site is near the crystallographic two-fold axis between the two alpha 4-turn-alpha 5 motifs. The principal binding interactions with the conjugate include specific electrostatic interactions between the peptide and the two subunits and a hydrophobic cavity found across the two-fold axis that accommodates the 3-iodobenzyl group. Thus, two identical, symmetry-related but mutually exclusive binding modes for the third conjugate are observed. The hydrophobic pocket is about 14 A from the hydroxyl group of Tyr-7 in the active site. This site is a potential transport binding site for hydrophobic molecules or their glutathione conjugates.

About this Structure

2GSQ is a Single protein structure of sequence from Ommastrephes sloani. Full crystallographic information is available from OCA.

Reference

Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography., Ji X, von Rosenvinge EC, Johnson WW, Armstrong RN, Gilliland GL, Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8208-13. PMID:8710848 Page seeded by OCA on Sun May 4 05:29:08 2008

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