2h0n

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{{Structure
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<!--
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|PDB= 2h0n |SIZE=350|CAPTION= <scene name='initialview01'>2h0n</scene>, resolution 1.53&Aring;
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The line below this paragraph, containing "STRUCTURE_2h0n", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:2hp+Binding+Site+For+Residue+A+9'>AC1</scene> and <scene name='pdbsite=AC2:2hp+Binding+Site+For+Residue+B+9'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=XAL:[(1S,4R,6R)-6-HYDROXY-4-(ADENIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XAL</scene>, <scene name='pdbligand=XCL:[(1S,4R,6R)-6-HYDROXY-4-(CYTOSIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XCL</scene>, <scene name='pdbligand=XGL:[(1S,4R,6R)-6-HYDROXY-4-(GUANIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XGL</scene>, <scene name='pdbligand=XTL:[(1S,4R,6R)-6-HYDROXY-4-(THYMIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XTL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2h0n| PDB=2h0n | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0n OCA], [http://www.ebi.ac.uk/pdbsum/2h0n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h0n RCSB]</span>
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}}
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'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''
'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''
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==About this Structure==
==About this Structure==
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2H0N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0N OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0N OCA].
==Reference==
==Reference==
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18198873 18198873]
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18198873 18198873]
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[[Category: Protein complex]]
 
[[Category: Meervelt, L Van.]]
[[Category: Meervelt, L Van.]]
[[Category: Robeyns, K.]]
[[Category: Robeyns, K.]]
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[[Category: cyclohexene nucleic acid]]
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[[Category: Cyclohexene nucleic acid]]
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[[Category: dna analogue]]
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[[Category: Dna analogue]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: left-handed]]
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[[Category: Left-handed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:26:48 2008''
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Revision as of 02:43, 4 May 2008

Template:STRUCTURE 2h0n

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC


Overview

CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:18198873 Page seeded by OCA on Sun May 4 05:43:55 2008

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