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2h3b

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[[Image:2h3b.gif|left|200px]]
[[Image:2h3b.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2h3b |SIZE=350|CAPTION= <scene name='initialview01'>2h3b</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_2h3b", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Nampt, Pbef1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_2h3b| PDB=2h3b | SCENE= }}
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|RELATEDENTRY=[[2h3d|2H3D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3b OCA], [http://www.ebi.ac.uk/pdbsum/2h3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h3b RCSB]</span>
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}}
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'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1'''
'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1'''
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[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: apoenzyme]]
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[[Category: Apoenzyme]]
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[[Category: type ii phsophoribosyltransferase]]
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[[Category: Type ii phsophoribosyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:49:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:24:49 2008''
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Revision as of 02:49, 4 May 2008

Image:2h3b.gif

Template:STRUCTURE 2h3b

Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1


Overview

Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

About this Structure

2H3B is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373 Page seeded by OCA on Sun May 4 05:49:00 2008

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