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2h5a

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[[Image:2h5a.gif|left|200px]]
[[Image:2h5a.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2h5a |SIZE=350|CAPTION= <scene name='initialview01'>2h5a</scene>, resolution 1.72&Aring;
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The line below this paragraph, containing "STRUCTURE_2h5a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=X1P:1-O-PHOSPHONO-ALPHA-D-XYLOPYRANOSE'>X1P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= algC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
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-->
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|DOMAIN=
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{{STRUCTURE_2h5a| PDB=2h5a | SCENE= }}
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|RELATEDENTRY=[[1k35|1K35]], [[1k2y|1K2Y]], [[1p5d|1P5D]], [[1p5g|1P5G]], [[1pcj|1PCJ]], [[1pcm|1PCM]], [[2h4l|2H4L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5a OCA], [http://www.ebi.ac.uk/pdbsum/2h5a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h5a RCSB]</span>
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}}
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'''Complex of the enzyme PMM/PGM with xylose 1-phosphate'''
'''Complex of the enzyme PMM/PGM with xylose 1-phosphate'''
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[[Category: Regni, C.]]
[[Category: Regni, C.]]
[[Category: Shackelford, G S.]]
[[Category: Shackelford, G S.]]
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[[Category: enzyme-ligand complex]]
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[[Category: Enzyme-ligand complex]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:53:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:25:40 2008''
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Revision as of 02:53, 4 May 2008

Image:2h5a.gif

Template:STRUCTURE 2h5a

Complex of the enzyme PMM/PGM with xylose 1-phosphate


Overview

Two complexes of the enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa with a slow substrate and with an inhibitor have been characterized by X-ray crystallography. Both ligands induce an interdomain rearrangement in the enzyme that creates a highly buried active site. Comparisons with enzyme-substrate complexes show that the inhibitor xylose 1-phosphate utilizes many of the previously observed enzyme-ligand interactions. In contrast, analysis of the ribose 1-phosphate complex reveals a combination of new and conserved enzyme-ligand interactions for binding. The ability of PMM/PGM to accommodate these two pentose phosphosugars in its active site may be relevant for future efforts towards inhibitor design.

About this Structure

2H5A is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor., Regni C, Shackelford GS, Beamer LJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt, 8):722-6. Epub 2006 Jul 24. PMID:16880541 Page seeded by OCA on Sun May 4 05:53:04 2008

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