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2hn7
From Proteopedia
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[[Image:2hn7.gif|left|200px]] | [[Image:2hn7.gif|left|200px]] | ||
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'''HLA-A*1101 in complex with HBV peptide homologue''' | '''HLA-A*1101 in complex with HBV peptide homologue''' | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Blicher, T.]] | [[Category: Blicher, T.]] | ||
| - | [[Category: | + | [[Category: Hbv]] |
| - | [[Category: | + | [[Category: Hepatitis b virus]] |
| - | [[Category: | + | [[Category: Hla]] |
| - | [[Category: | + | [[Category: Human leukocyte antigen]] |
| - | [[Category: | + | [[Category: Immunoglobulin family]] |
| - | [[Category: | + | [[Category: Major histocompatibility complex class i]] |
| - | [[Category: | + | [[Category: Mhc-i]] |
| - | [[Category: | + | [[Category: Peptide-mhc-complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:28:49 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:28, 4 May 2008
HLA-A*1101 in complex with HBV peptide homologue
Contents |
Overview
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
2HN7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892 Page seeded by OCA on Sun May 4 06:28:49 2008
