2hpm

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[[Image:2hpm.gif|left|200px]]
[[Image:2hpm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hpm |SIZE=350|CAPTION= <scene name='initialview01'>2hpm</scene>, resolution 3.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2hpm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3PO:TRIPHOSPHATE'>3PO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2hpm| PDB=2hpm | SCENE= }}
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|RELATEDENTRY=[[2hpi|2HPI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpm OCA], [http://www.ebi.ac.uk/pdbsum/2hpm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hpm RCSB]</span>
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}}
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'''Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III'''
'''Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III'''
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[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
[[Category: Wing, R A.]]
[[Category: Wing, R A.]]
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[[Category: nucleotidyltransferase fold]]
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[[Category: Nucleotidyltransferase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:33:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:33:36 2008''
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Revision as of 03:33, 4 May 2008

Image:2hpm.gif

Template:STRUCTURE 2hpm

Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III


Overview

The crystal structure of Thermus aquaticus DNA polymerase III alpha subunit reveals that the structure of the catalytic domain of the eubacterial replicative polymerase is unrelated to that of the eukaryotic replicative polymerase but rather belongs to the Polbeta-like nucleotidyltransferase superfamily. A model of the polymerase complexed with both DNA and beta-sliding clamp interacting with a reoriented binding domain and internal beta binding site was constructed that is consistent with existing biochemical data. Within the crystal, two C-terminal domains are interacting through a surface that is larger than many dimer interfaces. Since replicative polymerases of eubacteria and eukaryotes/archaea are not homologous, the nature of the replicative polymerase in the last common ancestor is unknown. Although other possibilities have been proposed, the plausibility of a ribozyme DNA polymerase should be considered.

About this Structure

2HPM is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases., Bailey S, Wing RA, Steitz TA, Cell. 2006 Sep 8;126(5):893-904. PMID:16959569 Page seeded by OCA on Sun May 4 06:33:13 2008

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