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2ht6

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[[Image:2ht6.jpg|left|200px]]
[[Image:2ht6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ht6 |SIZE=350|CAPTION= <scene name='initialview01'>2ht6</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_2ht6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= GEM, KIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2ht6| PDB=2ht6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ht6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ht6 OCA], [http://www.ebi.ac.uk/pdbsum/2ht6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ht6 RCSB]</span>
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}}
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'''Crystal structure of Human Gem G-domain bound to GDP'''
'''Crystal structure of Human Gem G-domain bound to GDP'''
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[[Category: Hirsch, J A.]]
[[Category: Hirsch, J A.]]
[[Category: Opatowsky, Y.]]
[[Category: Opatowsky, Y.]]
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[[Category: small g-protein]]
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[[Category: Small g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:40:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:03 2008''
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Revision as of 03:40, 4 May 2008

Image:2ht6.jpg

Template:STRUCTURE 2ht6

Crystal structure of Human Gem G-domain bound to GDP


Overview

Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.

About this Structure

2HT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-function studies of the G-domain from human gem, a novel small G-protein., Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA, FEBS Lett. 2006 Oct 30;580(25):5959-64. Epub 2006 Oct 6. PMID:17052716 Page seeded by OCA on Sun May 4 06:40:50 2008

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