2hvq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2hvq.gif|left|200px]]
[[Image:2hvq.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2hvq |SIZE=350|CAPTION= <scene name='initialview01'>2hvq</scene>, resolution 2.400&Aring;
+
The line below this paragraph, containing "STRUCTURE_2hvq", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=APK:5&#39;-O-[(S)-{[(5S)-5-AMINO-6-OXOHEXYL]AMINO}(HYDROXY)PHOSPHORYL]ADENOSINE'>APK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Y10A, 24.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2hvq| PDB=2hvq | SCENE= }}
-
|RELATEDENTRY=[[2hvr|2HVR]], [[2hvs|2HVS]], [[1s68|1s68]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvq OCA], [http://www.ebi.ac.uk/pdbsum/2hvq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hvq RCSB]</span>
+
-
}}
+
'''Structure of Adenylated full-length T4 RNA Ligase 2'''
'''Structure of Adenylated full-length T4 RNA Ligase 2'''
Line 27: Line 24:
[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
[[Category: Nandakumar, J.]]
[[Category: Nandakumar, J.]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: lysine adenylate]]
+
[[Category: Lysine adenylate]]
-
[[Category: rna]]
+
[[Category: Rna]]
-
[[Category: t4]]
+
[[Category: T4]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:46:15 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:36:04 2008''
+

Revision as of 03:46, 4 May 2008

Image:2hvq.gif

Template:STRUCTURE 2hvq

Structure of Adenylated full-length T4 RNA Ligase 2


Overview

T4 RNA ligase 2 (Rnl2) and kinetoplastid RNA editing ligases exemplify a family of RNA repair enzymes that seal 3'OH/5'PO(4) nicks in duplex RNAs via ligase adenylylation (step 1), AMP transfer to the nick 5'PO(4) (step 2), and attack by the nick 3'OH on the 5'-adenylylated strand to form a phosphodiester (step 3). Crystal structures are reported for Rnl2 at discrete steps along this pathway: the covalent Rnl2-AMP intermediate; Rnl2 bound to an adenylylated nicked duplex, captured immediately following step 2; and Rnl2 at an adenylylated nick in a state poised for step 3. These structures illuminate the stereochemistry of nucleotidyl transfer and reveal how remodeling of active-site contacts and conformational changes propel the ligation reaction forward. Mutational analysis and comparison of nick-bound structures of Rnl2 and human DNA ligase I highlight common and divergent themes of substrate recognition that can explain their specialization for RNA versus DNA repair.

About this Structure

2HVQ is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward., Nandakumar J, Shuman S, Lima CD, Cell. 2006 Oct 6;127(1):71-84. PMID:17018278 Page seeded by OCA on Sun May 4 06:46:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hvq"
Personal tools