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2hzm

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[[Image:2hzm.jpg|left|200px]]
[[Image:2hzm.jpg|left|200px]]
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{{Structure
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|GENE= SRB2, HRS2, MED20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SRB5, MED18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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{{STRUCTURE_2hzm| PDB=2hzm | SCENE= }}
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|RELATEDENTRY=[[1zp2|1ZP2]], [[1yke|1YKE]], [[1ykh|1YKH]], [[2hzs|2HZS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hzm OCA], [http://www.ebi.ac.uk/pdbsum/2hzm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hzm RCSB]</span>
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'''Structure of the Mediator head subcomplex Med18/20'''
'''Structure of the Mediator head subcomplex Med18/20'''
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[[Category: Rother, S.]]
[[Category: Rother, S.]]
[[Category: Straesser, K.]]
[[Category: Straesser, K.]]
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[[Category: beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:54:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:37:41 2008''
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Revision as of 03:54, 4 May 2008

Image:2hzm.jpg

Template:STRUCTURE 2hzm

Structure of the Mediator head subcomplex Med18/20


Overview

The Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here we show that the head subunits Med8, Med18 and Med20 form a subcomplex (Med8/18/20) with two submodules. The highly conserved N-terminal domain of Med8 forms one submodule that binds the TATA box-binding protein (TBP) in vitro and is essential in vivo. The second submodule consists of the C-terminal region of Med8 (Med8C), Med18 and Med20. X-ray analysis of this submodule reveals that Med18 and Med20 form related beta-barrel folds. A conserved putative protein-interaction face on the Med8C/18/20 submodule includes sites altered by srb mutations, which counteract defects resulting from Pol II truncation. Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators.

About this Structure

2HZM is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20., Lariviere L, Geiger S, Hoeppner S, Rother S, Strasser K, Cramer P, Nat Struct Mol Biol. 2006 Oct;13(10):895-901. Epub 2006 Sep 10. PMID:16964259 Page seeded by OCA on Sun May 4 06:54:19 2008

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