This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i1r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2i1r.jpg|left|200px]]
[[Image:2i1r.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2i1r |SIZE=350|CAPTION= <scene name='initialview01'>2i1r</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_2i1r", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=VXR:(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE'>VXR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2i1r| PDB=2i1r | SCENE= }}
-
|RELATEDENTRY=[[2hwh|2HWH]], [[2hwi|2HWI]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1r OCA], [http://www.ebi.ac.uk/pdbsum/2i1r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i1r RCSB]</span>
+
-
}}
+
'''Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure'''
'''Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure'''
Line 28: Line 25:
[[Category: Yan, S.]]
[[Category: Yan, S.]]
[[Category: Yao, N.]]
[[Category: Yao, N.]]
-
[[Category: allosteric inhibitor]]
+
[[Category: Allosteric inhibitor]]
-
[[Category: hcv]]
+
[[Category: Hcv]]
-
[[Category: hcv inhibitor complex]]
+
[[Category: Hcv inhibitor complex]]
-
[[Category: ns5b]]
+
[[Category: Ns5b]]
-
[[Category: rdrp]]
+
[[Category: Rdrp]]
-
[[Category: viral rna-directed rna polymerase]]
+
[[Category: Viral rna-directed rna polymerase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:58:16 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:38:30 2008''
+

Revision as of 03:58, 4 May 2008

Image:2i1r.jpg

Template:STRUCTURE 2i1r

Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure


Overview

Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2A, and confirmed the design.

About this Structure

2I1R is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure., Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. Epub 2006 Oct 4. PMID:17049849 Page seeded by OCA on Sun May 4 06:58:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i1r"
Personal tools