2i6e

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[[Image:2i6e.gif|left|200px]]
[[Image:2i6e.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2i6e |SIZE=350|CAPTION= <scene name='initialview01'>2i6e</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2i6e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= DR_0370 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 Deinococcus radiodurans])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1427 COG1427]</span>
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{{STRUCTURE_2i6e| PDB=2i6e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6e OCA], [http://www.ebi.ac.uk/pdbsum/2i6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i6e RCSB]</span>
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}}
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'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''
'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''
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[[Category: Swaminathan, S.]]
[[Category: Swaminathan, S.]]
[[Category: Tyagi, R.]]
[[Category: Tyagi, R.]]
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[[Category: hypothetical protein,pfam:duf178]]
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[[Category: Hypothetical protein,pfam:duf178]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc,10093b]]
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[[Category: Nysgxrc,10093b]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi-2]]
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[[Category: Psi-2]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: unknown function]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:07:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:22 2008''
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Revision as of 04:07, 4 May 2008

Image:2i6e.gif

Template:STRUCTURE 2i6e

Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178


Overview

BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.

About this Structure

2I6E is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300 Page seeded by OCA on Sun May 4 07:07:58 2008

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