2ja5

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[[Image:2ja5.jpg|left|200px]]
[[Image:2ja5.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ja5 |SIZE=350|CAPTION= <scene name='initialview01'>2ja5</scene>, resolution 3.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2ja5", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TT:[(1R,3R,4S,9R,10S,12R,15AS,15BR,18BR,18CS)-10-HYDROXY-15A,15B-DIMETHYL-13,15,16,18-TETRAOXOHEXADECAHYDRO-8H-9,12-EPOXY-1,4-METHANO-2,5,7-TRIOXA-12A,14,17,18A-TETRAAZACYCLOHEXADECA[1,2,3,4-DEF]BIPHENYLEN-3-YL]METHYL+DIHYDROGEN+PHOSPHATE'>TT</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ja5| PDB=2ja5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ja5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ja5 OCA], [http://www.ebi.ac.uk/pdbsum/2ja5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ja5 RCSB]</span>
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}}
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'''CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A'''
'''CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A'''
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[[Category: Cramer, P.]]
[[Category: Cramer, P.]]
[[Category: Hennecke, U.]]
[[Category: Hennecke, U.]]
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[[Category: arrest]]
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[[Category: Arrest]]
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[[Category: cpd]]
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[[Category: Cpd]]
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[[Category: damage recognition]]
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[[Category: Damage recognition]]
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[[Category: dna damage]]
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[[Category: Dna damage]]
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[[Category: dna lesion]]
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[[Category: Dna lesion]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: dna-directed rna polymerase]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: elongation complex]]
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[[Category: Elongation complex]]
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[[Category: lesion recognition]]
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[[Category: Lesion recognition]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: misincorporation]]
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[[Category: Misincorporation]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: photolesion]]
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[[Category: Photolesion]]
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[[Category: rna polymerase ii]]
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[[Category: Rna polymerase ii]]
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[[Category: stalling]]
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[[Category: Stalling]]
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[[Category: tcr]]
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[[Category: Tcr]]
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[[Category: thymine dimer]]
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[[Category: Thymine dimer]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription bubble]]
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[[Category: Transcription bubble]]
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[[Category: transcription- coupled repair,cyclobutane pyrimidine dimer]]
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[[Category: Transcription- coupled repair,cyclobutane pyrimidine dimer]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transferase/dna/rna]]
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[[Category: Transferase/dna/rna]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:35:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:55:12 2008''
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Revision as of 05:35, 4 May 2008

Image:2ja5.jpg

Template:STRUCTURE 2ja5

CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A


Overview

Cells use transcription-coupled repair (TCR) to efficiently eliminate DNA lesions such as ultraviolet light-induced cyclobutane pyrimidine dimers (CPDs). Here we present the structure-based mechanism for the first step in eukaryotic TCR, CPD-induced stalling of RNA polymerase (Pol) II. A CPD in the transcribed strand slowly passes a translocation barrier and enters the polymerase active site. The CPD 5'-thymine then directs uridine misincorporation into messenger RNA, which blocks translocation. Artificial replacement of the uridine by adenosine enables CPD bypass; thus, Pol II stalling requires CPD-directed misincorporation. In the stalled complex, the lesion is inaccessible, and the polymerase conformation is unchanged. This is consistent with nonallosteric recruitment of repair factors and excision of a lesion-containing DNA fragment in the presence of Pol II.

About this Structure

2JA5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

CPD damage recognition by transcribing RNA polymerase II., Brueckner F, Hennecke U, Carell T, Cramer P, Science. 2007 Feb 9;315(5813):859-62. PMID:17290000 Page seeded by OCA on Sun May 4 08:35:04 2008

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OCA

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